TY - JOUR
T1 - Propofol Frenzy
T2 - Clinical Spectrum in 3 Patients
AU - Carvalho, Diego Z.
AU - Townley, Ryan A.
AU - Burkle, Christopher M.
AU - Rabinstein, Alejandro A.
AU - Wijdicks, Eelco F.M.
N1 - Publisher Copyright:
© 2017 Mayo Foundation for Medical Education and Research
PY - 2017/11
Y1 - 2017/11
N2 - Postsedation neuroexcitation is sometimes attributed to intravenous injection of the sedative-hypnotic drug propofol. The movements associated with these events have strongly suggested convulsive activity, but they rarely have been comprehensively evaluated. We present video recordings of 3 healthy young patients who underwent elective surgery under conscious sedation and emerged from sedation with transient but repetitive violent motor activity and impaired consciousness. These manifestations required considerable mobilization of multiple health care workers to protect the patient from inflicting harm. All patients received propofol, and all fully recovered without adverse sequelae. We postulate that these movements are propofol related. Importantly, we found no evidence of seizures clinically or electrographically.
AB - Postsedation neuroexcitation is sometimes attributed to intravenous injection of the sedative-hypnotic drug propofol. The movements associated with these events have strongly suggested convulsive activity, but they rarely have been comprehensively evaluated. We present video recordings of 3 healthy young patients who underwent elective surgery under conscious sedation and emerged from sedation with transient but repetitive violent motor activity and impaired consciousness. These manifestations required considerable mobilization of multiple health care workers to protect the patient from inflicting harm. All patients received propofol, and all fully recovered without adverse sequelae. We postulate that these movements are propofol related. Importantly, we found no evidence of seizures clinically or electrographically.
UR - http://www.scopus.com/inward/record.url?scp=85037694180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037694180&partnerID=8YFLogxK
U2 - 10.1016/j.mayocp.2017.08.022
DO - 10.1016/j.mayocp.2017.08.022
M3 - Article
C2 - 29101936
AN - SCOPUS:85037694180
SN - 0025-6196
VL - 92
SP - 1682
EP - 1687
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 11
ER -