Prolonged anuria complicating primary sclerosing cholangitis: Successful outcome following orthotopic liver transplantation

Matthew D. Griffin, Joseph P. Grande, Russell H. Wiesner, Jorge A. Velosa

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A 49-year-old man with progressive obstructive Jaundice secondary to primary sclerosing cholangitis developed acute, anuric renal failure requiring prolonged hemodialysis. Renal biopsy showed evidence of tubular epithelial toxicity, pigmented casts, interstitial fibrosis, and ischemic glomerular changes. After orthotopic liver transplantation (OLT), there was an immediate return of urine output. The introduction of tacrollmus (FK506) was delayed for 3 weeks after transplantation, during which time a gradual improvement in renal function occurred. Renal function remained stable 1 year later at level of moderate impairment with good hepatic function.

Original languageEnglish (US)
Pages (from-to)360-363
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume31
Issue number2
DOIs
StatePublished - Feb 1998

Keywords

  • Hepatorenal syndrome
  • Orthotopic liver transplantation
  • Primary sclerosing cholangitis
  • Renal failure, acute
  • Tacrolimus

ASJC Scopus subject areas

  • Nephrology

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