TY - JOUR
T1 - Prolonged anuria complicating primary sclerosing cholangitis
T2 - Successful outcome following orthotopic liver transplantation
AU - Griffin, Matthew D.
AU - Grande, Joseph P.
AU - Wiesner, Russell H.
AU - Velosa, Jorge A.
PY - 1998/2
Y1 - 1998/2
N2 - A 49-year-old man with progressive obstructive Jaundice secondary to primary sclerosing cholangitis developed acute, anuric renal failure requiring prolonged hemodialysis. Renal biopsy showed evidence of tubular epithelial toxicity, pigmented casts, interstitial fibrosis, and ischemic glomerular changes. After orthotopic liver transplantation (OLT), there was an immediate return of urine output. The introduction of tacrollmus (FK506) was delayed for 3 weeks after transplantation, during which time a gradual improvement in renal function occurred. Renal function remained stable 1 year later at level of moderate impairment with good hepatic function.
AB - A 49-year-old man with progressive obstructive Jaundice secondary to primary sclerosing cholangitis developed acute, anuric renal failure requiring prolonged hemodialysis. Renal biopsy showed evidence of tubular epithelial toxicity, pigmented casts, interstitial fibrosis, and ischemic glomerular changes. After orthotopic liver transplantation (OLT), there was an immediate return of urine output. The introduction of tacrollmus (FK506) was delayed for 3 weeks after transplantation, during which time a gradual improvement in renal function occurred. Renal function remained stable 1 year later at level of moderate impairment with good hepatic function.
KW - Hepatorenal syndrome
KW - Orthotopic liver transplantation
KW - Primary sclerosing cholangitis
KW - Renal failure, acute
KW - Tacrolimus
UR - http://www.scopus.com/inward/record.url?scp=0031931261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031931261&partnerID=8YFLogxK
U2 - 10.1053/ajkd.1998.v31.pm9469512
DO - 10.1053/ajkd.1998.v31.pm9469512
M3 - Article
C2 - 9469512
AN - SCOPUS:0031931261
SN - 0272-6386
VL - 31
SP - 360
EP - 363
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 2
ER -