Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy

DIAN Investigators

Research output: Contribution to journalArticlepeer-review


Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022.

Original languageEnglish (US)
JournalAnnals of neurology
StateAccepted/In press - 2022

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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