Progressive multifocal leukoencephalopathy

A review of the pathology and pathogenesis

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Progressive multifocal leukoencephalopathy is an important viral opportunistic infection of oligodendrocytes leading to direct demyelination. Virus is likely disseminated to the brain via the blood. However, the timing of that dissemination with relationship to clinical disease is unknown. Important clues about viral pathogenesis have been learned by applying molecular in situ techniques to diseased brain. The oligodendrocyte is the primary target for JC virus infection, and its death is the primary reason for demyelination. Bizarre astrocytes show limited viral DNA replication but are abortively infected. Although lymphoid organs can be infected by JC virus, there is no definitive evidence that lymphoid cells carry virus into the brain at the time of immunosuppression. JC virus may be reactivated from a latent state in both the brain and in non‐central nervous system (CNS) organs at the time of immunosuppression, leading to clinical disease. Future sensitive in situ studies will likely resolve controversies about pathogenesis. © 1995 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)302-311
Number of pages10
JournalMicroscopy Research and Technique
Volume32
Issue number4
DOIs
StatePublished - Jan 1 1995

Fingerprint

JC Virus
Progressive Multifocal Leukoencephalopathy
pathogenesis
pathology
viruses
Pathology
Viruses
Oligodendroglia
Demyelinating Diseases
brain
Virus Diseases
Brain
Immunosuppression
immunosuppression
infectious diseases
organs
Opportunistic Infections
Viral DNA
Brain Diseases
DNA Replication

Keywords

  • In situ hybridization
  • JC virus
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology

Cite this

Progressive multifocal leukoencephalopathy : A review of the pathology and pathogenesis. / Aksamit, Allen Jr.

In: Microscopy Research and Technique, Vol. 32, No. 4, 01.01.1995, p. 302-311.

Research output: Contribution to journalArticle

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