Progressive Multifocal Leukoencephalopathy: A rare infectious complication following allogeneic hematopoietic cell transplantation (HCT)

Gregory P. Kaufman, Allen Jr. Aksamit, Christopher Jon Klein, Eunhee S. Yi, David R. Delone, Mark R Litzow

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Progressive multifocal leukoencephalopathy (PML), a demyelinating disorder caused by brain infection with JC virus, is a neurological complication of immunocompromised states and immunosuppressive therapies. While most commonly seen in the HIV/AIDS population, patients with hematologic malignancies are also at risk following treatment protocols including monoclonal antibodies such as rituximab and after hematopoietic stem cell transplantation. Here, we present the case of PML following allogeneic HCT that highlights potential diagnostic difficulties. We also review the literature regarding PML following HCT and described therapies employed to attempt to treat this disorder.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalEuropean Journal of Haematology
Volume92
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Progressive Multifocal Leukoencephalopathy
Cell Transplantation
JC Virus
Hematopoietic Stem Cell Transplantation
Demyelinating Diseases
Hematologic Neoplasms
Immunosuppressive Agents
Clinical Protocols
Acquired Immunodeficiency Syndrome
Monoclonal Antibodies
HIV
Brain
Therapeutics
Infection
Population

Keywords

  • Allogeneic bone marrow transplantation
  • Encephalitis
  • Hematopoietic cell transplantation
  • Immunocompromised host
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Hematology

Cite this

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