Prognostic value of cytogenetic analysis in human cerebral astrocytomas

David W. Kimmel, Judith R. O'Fallon, Bernd W. Scheithauer, Patrick J. Kelly, Gordon W. Dewald, Robert Brian Jenkins

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cytogenetic analysis has become an important part of the diagnostic evaluation of most hematological neoplasms. However, there is limited information on the value of cytogenetic analysis in most solid tumors, including cerebral astrocytomas. This report summarizes a prospective cytogenetic study of 99 human cerebral astrocytomas, 16 mixed oligoastrocytomas, and 2 gliosarcomas. The cytogenetic procedure involved in situ culture and robotic harvesting techniques. Correlative clinical and survival data were available on all patients. We successfully cultured and obtained suitable metaphases in 107 of the 117 tumors. One or more chromosomally abnormal clones were observed in 72 tumors, and nonclonal or normal karyotypes were observed in 35 tumors. In a multivariate analysis, survival time was significantly better in patients whose tumors had normal or nonclonal karyotypes on cytogenetic analyses than in those whose tumors had clonal abnormalities (p = 0.0071). Our study demonstrates that cytogenetic analysis provides independent prognostic information in patients with cerebral astrocytomas.

Original languageEnglish (US)
Pages (from-to)534-542
Number of pages9
JournalAnnals of Neurology
Volume31
Issue number5
StatePublished - May 1992

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Cytogenetic Analysis
Astrocytoma
Neoplasms
Karyotype
Cytogenetics
Gliosarcoma
Survival
Robotics
Hematologic Neoplasms
Metaphase
Multivariate Analysis
Clone Cells
Prospective Studies

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kimmel, D. W., O'Fallon, J. R., Scheithauer, B. W., Kelly, P. J., Dewald, G. W., & Jenkins, R. B. (1992). Prognostic value of cytogenetic analysis in human cerebral astrocytomas. Annals of Neurology, 31(5), 534-542.

Prognostic value of cytogenetic analysis in human cerebral astrocytomas. / Kimmel, David W.; O'Fallon, Judith R.; Scheithauer, Bernd W.; Kelly, Patrick J.; Dewald, Gordon W.; Jenkins, Robert Brian.

In: Annals of Neurology, Vol. 31, No. 5, 05.1992, p. 534-542.

Research output: Contribution to journalArticle

Kimmel, DW, O'Fallon, JR, Scheithauer, BW, Kelly, PJ, Dewald, GW & Jenkins, RB 1992, 'Prognostic value of cytogenetic analysis in human cerebral astrocytomas', Annals of Neurology, vol. 31, no. 5, pp. 534-542.
Kimmel DW, O'Fallon JR, Scheithauer BW, Kelly PJ, Dewald GW, Jenkins RB. Prognostic value of cytogenetic analysis in human cerebral astrocytomas. Annals of Neurology. 1992 May;31(5):534-542.
Kimmel, David W. ; O'Fallon, Judith R. ; Scheithauer, Bernd W. ; Kelly, Patrick J. ; Dewald, Gordon W. ; Jenkins, Robert Brian. / Prognostic value of cytogenetic analysis in human cerebral astrocytomas. In: Annals of Neurology. 1992 ; Vol. 31, No. 5. pp. 534-542.
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