Prognostic significance of p27, Ki-67, and topoisomerase IIα expression in clinically nonfunctioning pancreatic endocrine tumors

Hee Jin Chang, Kenneth P. Batts, Ricardo V. Lloyd, Thomas J. Sebo, Geoffrey B. Thompson, Christine M. Lohse, Shane V. Pankratz

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Nonfunctioning islet cell tumors or pancreatic endocrine tumors are the most common type of malignant islet cell tumor. Although previously detected usually at an advanced stage because of mass effect, the early detection rate of small localized disease has been increasing. To date it has been difficult to predict the clinical behavior in localized regional nonfunctioning tumors. To investigate potential markers predicting malignancy and poor prognosis in nonfunctioning pancreatic endocrine tumors, we analyzed the expression of Ki-67, topoisomerase IIα (Topollα), and p27, as well as a variety of clinicopathologic parameters in 76 cases of nonfunctioning islet cell tumors (23 benign cases and 53 malignant cases). Ki-67, Topollα, and p27 labeling indices were significantly different between benign and malignant tumors. Expression of Ki-67, Topollα, and p27 were associated with survival in patients with a malignant tumor in a univariate setting. However, only p27 and Topollα were jointly associated with survival in multivariate analysis. Immunohistochemical staining for p27, Topollα, and Ki-67 can be helpful in the diagnosis of nonfunctioning pancreatic endocrine tumor. Analysis of p27 and Topollα may also have potential utility as prognostic factors for malignant tumors.

Original languageEnglish (US)
Pages (from-to)229-241
Number of pages13
JournalEndocrine Pathology
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2000

Keywords

  • Ki-67
  • Nonfunctioning pancreatic endocrine tumor
  • P27
  • Prognosis
  • Topoisomerase IIα

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Chang, H. J., Batts, K. P., Lloyd, R. V., Sebo, T. J., Thompson, G. B., Lohse, C. M., & Pankratz, S. V. (2000). Prognostic significance of p27, Ki-67, and topoisomerase IIα expression in clinically nonfunctioning pancreatic endocrine tumors. Endocrine Pathology, 11(3), 229-241. https://doi.org/10.1385/EP:11:3:229