Prognostic implications of post-percutaneous coronary intervention neutrophil-to-lymphocyte ratio on infarct size and clinical outcomes in patients with acute myocardial infarction

David Hong, Ki Hong Choi, Young Bin Song, Joo Myung Lee, Taek Kyu Park, Jeong Hoon Yang, Joo Yong Hahn, Jin Ho Choi, Seung Hyuk Choi, Sung Mok Kim, Yeonhyeon Choe, Eun Kyoung Kim, Sung A. Chang, Sang Chol Lee, Jae Kuen Oh, Hyeon Cheol Gwon

Research output: Contribution to journalArticle

Abstract

This study evaluated the prognostic implications of post-percutaneous coronary intervention (PCI) neutrophil-to-lymphocyte ratio (NLR) in patients with acute myocardial infarction (AMI). A total of 309 patients with AMI who underwent cardiac magnetic resonance imaging (CMR) and a complete blood cell count within 24 hours before and after PCI were enrolled. Primary outcome was infarct size. Patients were assigned to high (n = 118) or low (n = 191) NLR groups according to the best cut-off value of 3.88. Infarct size (% of total left ventricular mass) was significantly higher in the high NLR group than in the low NLR group (24.1 ± 11.0 vs. 16.7 ± 9.1, p < 0.001). Post-PCI NLR ≥ 3.88 was associated with risk of a large-sized infarction (≥20%) (OR 2.91, 95% CI 1.73–4.88, p < 0.001). The risk of MACE was also significantly higher in the high NLR group than in the low NLR group (15.8% vs. 7.4%, HR 2.60, 95% CI 1.21–5.60, p = 0.015). Among patients with AMI who underwent PCI, high post-PCI NLR value was associated with higher risk of large-sized infarction as measured by CMR, as well as adverse clinical outcomes. Our findings suggest that post-PCI NLR is a useful tool for risk assessment in patients with AMI who undergo PCI.

Original languageEnglish (US)
Article number9646
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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Percutaneous Coronary Intervention
Neutrophils
Myocardial Infarction
Lymphocytes
Blood Cell Count
Infarction
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • General

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Prognostic implications of post-percutaneous coronary intervention neutrophil-to-lymphocyte ratio on infarct size and clinical outcomes in patients with acute myocardial infarction. / Hong, David; Choi, Ki Hong; Song, Young Bin; Lee, Joo Myung; Park, Taek Kyu; Yang, Jeong Hoon; Hahn, Joo Yong; Choi, Jin Ho; Choi, Seung Hyuk; Kim, Sung Mok; Choe, Yeonhyeon; Kim, Eun Kyoung; Chang, Sung A.; Lee, Sang Chol; Oh, Jae Kuen; Gwon, Hyeon Cheol.

In: Scientific reports, Vol. 9, No. 1, 9646, 01.12.2019.

Research output: Contribution to journalArticle

Hong, D, Choi, KH, Song, YB, Lee, JM, Park, TK, Yang, JH, Hahn, JY, Choi, JH, Choi, SH, Kim, SM, Choe, Y, Kim, EK, Chang, SA, Lee, SC, Oh, JK & Gwon, HC 2019, 'Prognostic implications of post-percutaneous coronary intervention neutrophil-to-lymphocyte ratio on infarct size and clinical outcomes in patients with acute myocardial infarction', Scientific reports, vol. 9, no. 1, 9646. https://doi.org/10.1038/s41598-019-46117-8
Hong, David ; Choi, Ki Hong ; Song, Young Bin ; Lee, Joo Myung ; Park, Taek Kyu ; Yang, Jeong Hoon ; Hahn, Joo Yong ; Choi, Jin Ho ; Choi, Seung Hyuk ; Kim, Sung Mok ; Choe, Yeonhyeon ; Kim, Eun Kyoung ; Chang, Sung A. ; Lee, Sang Chol ; Oh, Jae Kuen ; Gwon, Hyeon Cheol. / Prognostic implications of post-percutaneous coronary intervention neutrophil-to-lymphocyte ratio on infarct size and clinical outcomes in patients with acute myocardial infarction. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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abstract = "This study evaluated the prognostic implications of post-percutaneous coronary intervention (PCI) neutrophil-to-lymphocyte ratio (NLR) in patients with acute myocardial infarction (AMI). A total of 309 patients with AMI who underwent cardiac magnetic resonance imaging (CMR) and a complete blood cell count within 24 hours before and after PCI were enrolled. Primary outcome was infarct size. Patients were assigned to high (n = 118) or low (n = 191) NLR groups according to the best cut-off value of 3.88. Infarct size ({\%} of total left ventricular mass) was significantly higher in the high NLR group than in the low NLR group (24.1 ± 11.0 vs. 16.7 ± 9.1, p < 0.001). Post-PCI NLR ≥ 3.88 was associated with risk of a large-sized infarction (≥20{\%}) (OR 2.91, 95{\%} CI 1.73–4.88, p < 0.001). The risk of MACE was also significantly higher in the high NLR group than in the low NLR group (15.8{\%} vs. 7.4{\%}, HR 2.60, 95{\%} CI 1.21–5.60, p = 0.015). Among patients with AMI who underwent PCI, high post-PCI NLR value was associated with higher risk of large-sized infarction as measured by CMR, as well as adverse clinical outcomes. Our findings suggest that post-PCI NLR is a useful tool for risk assessment in patients with AMI who undergo PCI.",
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AU - Hong, David

AU - Choi, Ki Hong

AU - Song, Young Bin

AU - Lee, Joo Myung

AU - Park, Taek Kyu

AU - Yang, Jeong Hoon

AU - Hahn, Joo Yong

AU - Choi, Jin Ho

AU - Choi, Seung Hyuk

AU - Kim, Sung Mok

AU - Choe, Yeonhyeon

AU - Kim, Eun Kyoung

AU - Chang, Sung A.

AU - Lee, Sang Chol

AU - Oh, Jae Kuen

AU - Gwon, Hyeon Cheol

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N2 - This study evaluated the prognostic implications of post-percutaneous coronary intervention (PCI) neutrophil-to-lymphocyte ratio (NLR) in patients with acute myocardial infarction (AMI). A total of 309 patients with AMI who underwent cardiac magnetic resonance imaging (CMR) and a complete blood cell count within 24 hours before and after PCI were enrolled. Primary outcome was infarct size. Patients were assigned to high (n = 118) or low (n = 191) NLR groups according to the best cut-off value of 3.88. Infarct size (% of total left ventricular mass) was significantly higher in the high NLR group than in the low NLR group (24.1 ± 11.0 vs. 16.7 ± 9.1, p < 0.001). Post-PCI NLR ≥ 3.88 was associated with risk of a large-sized infarction (≥20%) (OR 2.91, 95% CI 1.73–4.88, p < 0.001). The risk of MACE was also significantly higher in the high NLR group than in the low NLR group (15.8% vs. 7.4%, HR 2.60, 95% CI 1.21–5.60, p = 0.015). Among patients with AMI who underwent PCI, high post-PCI NLR value was associated with higher risk of large-sized infarction as measured by CMR, as well as adverse clinical outcomes. Our findings suggest that post-PCI NLR is a useful tool for risk assessment in patients with AMI who undergo PCI.

AB - This study evaluated the prognostic implications of post-percutaneous coronary intervention (PCI) neutrophil-to-lymphocyte ratio (NLR) in patients with acute myocardial infarction (AMI). A total of 309 patients with AMI who underwent cardiac magnetic resonance imaging (CMR) and a complete blood cell count within 24 hours before and after PCI were enrolled. Primary outcome was infarct size. Patients were assigned to high (n = 118) or low (n = 191) NLR groups according to the best cut-off value of 3.88. Infarct size (% of total left ventricular mass) was significantly higher in the high NLR group than in the low NLR group (24.1 ± 11.0 vs. 16.7 ± 9.1, p < 0.001). Post-PCI NLR ≥ 3.88 was associated with risk of a large-sized infarction (≥20%) (OR 2.91, 95% CI 1.73–4.88, p < 0.001). The risk of MACE was also significantly higher in the high NLR group than in the low NLR group (15.8% vs. 7.4%, HR 2.60, 95% CI 1.21–5.60, p = 0.015). Among patients with AMI who underwent PCI, high post-PCI NLR value was associated with higher risk of large-sized infarction as measured by CMR, as well as adverse clinical outcomes. Our findings suggest that post-PCI NLR is a useful tool for risk assessment in patients with AMI who undergo PCI.

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