Prognostic factors in patients irradiated for recurrent head-and-neck cancer

Daniel Seidl, Steven E. Schild, Barbara Wollenberg, Samer G. Hakim, Dirk Rades

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background/Aim: Many patients with recurrent head-and-neck cancer have poor outcomes. Predictive factors allowing judgment of the patient's prognosis are important for treatment individualization. This study aimed to identify such factors after irradiation of locoregional recurrence. Patients and Methods: In 60 patients irradiated for locoregionally recurrent head-and-neck cancer, 12 factors were evaluated regarding freedom from second locoregional recurrence and survival, namely gender, tumor site, initial tumor stage, primary treatment, time between cancer diagnosis and irradiation of locoregional recurrence, age, performance score, tumor and nodal category of recurrence, upfront surgery, radiation dose and concurrent chemotherapy. Results: On Cox regression analysis, performance score (p=0.002) and nodal category (p=0.004) significantly affected survival. Good performance score (p=0.021) and low nodal category (p=0.002) were also significantly associated with freedom from a second recurrence. Conclusion: Independent predictors of survival and freedom from second locoregional recurrence were identified as factors facilitating individualized treatment of patients with locoregionally recurrent head-and-neck cancer.

Original languageEnglish (US)
Pages (from-to)6547-6550
Number of pages4
JournalAnticancer research
Volume36
Issue number12
DOIs
StatePublished - Dec 2016

Keywords

  • Head-and-neck cancer
  • Outcomes
  • Prognoses
  • Radiation therapy
  • Recurrence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Seidl, D., Schild, S. E., Wollenberg, B., Hakim, S. G., & Rades, D. (2016). Prognostic factors in patients irradiated for recurrent head-and-neck cancer. Anticancer research, 36(12), 6547-6550. https://doi.org/10.21873/anticanres.11257