Prognostic factors in kidney transplantation in the septuagenarian: a multicenter analysis

Hector Saucedo-Crespo, Danielle J. Haakinson, Kristopher P. Croome, Martin Mai, C. Burcin Taner, Raymond L. Heilman, Thomas Gonwa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Kidney transplant (KT) programs have extended recipient eligibility to those who were previously excluded due to advanced age. We aimed to determine the outcomes of the patients ≥70 years undergoing KT and investigate factors predicting survival. Two thousand six hundred and twenty-four KT patients between 2003 and 2013 at two institutions were divided into two groups; those ≥70 years (n=300) and those <70 years (n=2324) at the time of KT. Patient survival at 1, 3, and 5 years was 95%, 86%, and 77% in ≥70 years of age group and 98%, 95%, and 90% in the <70 years group (P<.001). When graft loss due to death was censored, graft survival was not significantly different between the two groups (P=.18). On multivariable analysis, the significant predictors of inferior survival in patients ≥70 years included: body mass index (BMI)>30 kg/m2 (hazard ratio [HR] 1.07; P=.01), panel reactive antibody (PRA)>20% (HR 2.38; P=.01), previous coronary artery bypass grafting (CABG; HR 1.95; P=.03) and peripheral vascular disease (PVD; HR 2.60; P=.04). Acceptable outcomes can be achieved in KT recipients ≥70 years. Caution should be used when listing these patients if they have BMI>30 kg/m2, PRA>20%, CABG or PVD.

Original languageEnglish (US)
Pages (from-to)828-835
Number of pages8
JournalClinical Transplantation
Volume30
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Kidney Transplantation
Kidney
Transplants
Peripheral Vascular Diseases
Antibodies
Coronary Artery Bypass
Survival

Keywords

  • elderly
  • graft loss
  • kidney transplantation
  • mortality

ASJC Scopus subject areas

  • Medicine(all)
  • Transplantation

Cite this

Saucedo-Crespo, H., Haakinson, D. J., Croome, K. P., Mai, M., Taner, C. B., Heilman, R. L., & Gonwa, T. (2016). Prognostic factors in kidney transplantation in the septuagenarian: a multicenter analysis. Clinical Transplantation, 30(7), 828-835. https://doi.org/10.1111/ctr.12756

Prognostic factors in kidney transplantation in the septuagenarian : a multicenter analysis. / Saucedo-Crespo, Hector; Haakinson, Danielle J.; Croome, Kristopher P.; Mai, Martin; Taner, C. Burcin; Heilman, Raymond L.; Gonwa, Thomas.

In: Clinical Transplantation, Vol. 30, No. 7, 01.07.2016, p. 828-835.

Research output: Contribution to journalArticle

Saucedo-Crespo, H, Haakinson, DJ, Croome, KP, Mai, M, Taner, CB, Heilman, RL & Gonwa, T 2016, 'Prognostic factors in kidney transplantation in the septuagenarian: a multicenter analysis', Clinical Transplantation, vol. 30, no. 7, pp. 828-835. https://doi.org/10.1111/ctr.12756
Saucedo-Crespo, Hector ; Haakinson, Danielle J. ; Croome, Kristopher P. ; Mai, Martin ; Taner, C. Burcin ; Heilman, Raymond L. ; Gonwa, Thomas. / Prognostic factors in kidney transplantation in the septuagenarian : a multicenter analysis. In: Clinical Transplantation. 2016 ; Vol. 30, No. 7. pp. 828-835.
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