@article{e71ee3eba25a4ee1b048aaccaf4c2618,
title = "Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: Results from the ovarian cancer association consortium pooled analysis",
abstract = "There is evidence that progesterone plays a role in the aetiology of invasive epithelial ovarian cancer. Therefore, genes involved in pathways that regulate progesterone may be candidates for susceptibility to this disease. Previous studies have suggested that genetic variants in the progesterone receptor gene (PGR) may be associated with ovarian cancer risk, although results have been inconsistent. We have established an international consortium to pool resources and data from many ovarian cancer case-control studies in an effort to identify variants that influence risk. In this study, three PGR single nucleotide polymorphisms (SNPs), for which previous data have suggested they affect ovarian cancer risk, were examined. These were +331 C/T (rs10895068), PROGINS (rs1042838), and a 3′ variant (rs608995). A total of 4788 ovarian cancer cases and 7614 controls from 12 case-control studies were included in this analysis. Unconditional logistic regression was used to model the association between each SNP and ovarian cancer risk and two-sided P-values are reported. Overall, risk of ovarian cancer was not associated with any of the three variants studied. However, in histopathological subtype analyses, we found a statistically significant association between risk of endometrioid ovarian cancer and the PROGINS allele (n=651, OR=1.17, 95% CI=1.01-1.36, P=0.036). We also observed borderline evidence of an association between risk of endometrioid ovarian cancer and the +331C/T variant (n=725 cases; OR=0.80, 95% CI 0.62-1.04, P=0.100). These data suggest that while these three variants in the PGR are not associated with ovarian cancer overall, the PROGINS variant may play a modest role in risk of endometrioid ovarian cancer.",
keywords = "Endometrioid ovarian cancer, Ovarian cancer, PROGINS, Pooled analyses, Progesterone receptor, SNPs",
author = "Pearce, {C. L.} and Wu, {A. H.} and Gayther, {S. A.} and Bale, {A. E.} and Beck, {P. A.} and J. Beesley and S. Chanock and Cramer, {D. W.} and R. DiCioccio and R. Edwards and Fredericksen, {Z. S.} and M. Garcia-Closas and Goode, {E. L.} and Green, {A. C.} and Hartmann, {L. C.} and E. Hogdall and Kj{\ae}r, {S. K.} and J. Lissowska and V. McGuire and F. Modugno and K. Moysich and Ness, {R. B.} and Ramus, {S. J.} and Risch, {H. A.} and Sellers, {T. A.} and H. Song and Stram, {D. O.} and Terry, {K. L.} and Webb, {P. M.} and Whiteman, {D. C.} and Whittemore, {A. S.} and W. Zheng and Pharoah, {P. D.P.} and G. Chenevix-Trench and Pike, {M. C.} and J. Schildkraut and A. Berchuck",
note = "Funding Information: Genotyping was supported by a grant from the Ovarian Cancer Research Fund provided by the family and friends of Kathryn Sladek Smith (PI: Andrew Berchuck). Support was provided by: US Army Medical Research and Material Command under DAMD17-01-1-0729, the Cancer Council Tasmania, and Cancer Foundation of Western Australia (Australian Ovarian Cancer Study); The National Health and Medical Research Council of Australia (199600) (Australian Cancer Study); US Public Health Service Grants 5R01-CA074850 and 5R01-CA080742 (CONN), the Roswell Park Alliance, and the National Cancer Institute (CA71966 and Core Grant CA16056; Family Registry for Ovarian Cancer Study), Mermaid1 (MALOVA), The Danish Cancer Society (MALOVA), National Cancer Institute, NIH, Bethesda (RO1 CA 61107) (MALOVA), the Fraternal Order of Eagles Cancer Research Fund and the Minnesota Ovarian Cancer Alliance (Mayo Clinic Ovarian Cancer Case–Control Study), Intramural Funds from the National Cancer Institute, NIH, Bethesda, MD (Polish Ovarian Cancer Study); SEARCH is supported by a grant from Cancer Research UK; California Cancer Research Program Grants 00-01389V-20170 and 2110200, US Public Health Service Grants CA14089, CA17054, CA61132, CA63464, N01-PC-67010 and R03-CA113148, and California Department of Health Services subcontract 050-E8709 as part of its statewide cancer reporting programme (University of Southern California). GCT and DW are supported by fellowships from the NHMRC; PW is supported by a fellowship from the Queensland Cancer Fund; HS was funded by a grant from WellBeing of women; PDPP is a Senior Clinical Research Fellow of Cancer Research UK. The full AOCS Study Group is listed on http://www.AOCStudy.org/.",
year = "2008",
month = jan,
day = "29",
doi = "10.1038/sj.bjc.6604170",
language = "English (US)",
volume = "98",
pages = "282--288",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "2",
}