TY - JOUR
T1 - Progesterone receptor gene polymorphisms and risk of endometriosis
T2 - Results from an international collaborative effort
AU - Near, Aimee M.
AU - Wu, Anna H.
AU - Templeman, Claire
AU - Van Den Berg, David J.
AU - Doherty, Jennifer A.
AU - Rossing, Mary Anne
AU - Goode, Ellen L.
AU - Cunningham, Julie M.
AU - Vierkant, Robert A.
AU - Fridley, Brooke L.
AU - Chenevix-Trench, Georgia
AU - Webb, Penelope M.
AU - Kjær, Susanne Krüger
AU - Hogdall, Estrid
AU - Gayther, Simon A.
AU - Ramus, Susan J.
AU - Menon, Usha
AU - Gentry-Maharaj, Aleksandra
AU - Schildkraut, Joellen M.
AU - Moorman, Patricia G.
AU - Palmieri, Rachel T.
AU - Ness, Roberta B.
AU - Moysich, Kirsten
AU - Cramer, Daniel W.
AU - Terry, Kathryn L.
AU - Vitonis, Allison F.
AU - Pike, Malcolm C.
AU - Berchuck, Andrew
AU - Pearce, Celeste Leigh
N1 - Funding Information:
The AOCS Management Group (D. Bowtell, B.V.Sc (Hons), B.A.Sci., Ph.D., Georgia Chenevix-Trench, Ph.D., A. deFazio, Ph.D., D. Gertig, M.B.B.S., Ph.D., A. Green, M.B.B.S., Ph.D., Penelope M. Webb, Ph.D.) gratefully acknowledges the contribution of all the clinical and scientific collaborators (see http://www.aocstudy.org/ ). The ACS Management Group comprises A. Green, M.B.B.S., Ph.D., P. Parsons, Ph.D., N. Hayward, Ph.D., Penelope M. Webb, Ph.D., and D. Whiteman, M.B.B.S., Ph.D. The authors are grateful to the family and friends of Kathryn Sladek Smith for their generous support of OCAC through their donations to the Ovarian Cancer Research Fund . The authors thank all the individuals who took part in these studies and the project staff of all the participating studies.
PY - 2011/1
Y1 - 2011/1
N2 - Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.
AB - Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.
KW - Endometriosis
KW - PROGINS
KW - ovarian cancer
KW - progesterone receptor
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U2 - 10.1016/j.fertnstert.2010.06.059
DO - 10.1016/j.fertnstert.2010.06.059
M3 - Article
C2 - 20719308
AN - SCOPUS:78650417362
VL - 95
SP - 40
EP - 45
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 1
ER -