Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort

Aimee M. Near; Anna H. Wu; Claire Templeman; David J. Van Den Berg; Jennifer A. Doherty; Mary Anne Rossing; Ellen L. Goode; Julie M. Cunningham; Robert A. Vierkant; Brooke L. Fridley; Georgia Chenevix-Trench; Penelope M. Webb; Susanne Krüger Kjær; Estrid Hogdall; Simon A. Gayther; Susan J. Ramus; Usha Menon; Aleksandra Gentry-Maharaj; Joellen M. Schildkraut; Patricia G. Moorman; Rachel T. Palmieri; Roberta B. Ness; Kirsten Moysich; Daniel W. Cramer; Kathryn L. Terry; Allison F. Vitonis; Malcolm C. Pike; Andrew Berchuck; Celeste Leigh Pearce

doi:10.1016/j.fertnstert.2010.06.059

Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort

Aimee M. Near, Anna H. Wu, Claire Templeman, David J. Van Den Berg, Jennifer A. Doherty, Mary Anne Rossing, Ellen L. Goode, Julie M. Cunningham, Robert A. Vierkant, Brooke L. Fridley, Georgia Chenevix-Trench, Penelope M. Webb, Susanne Krüger Kjær, Estrid Hogdall, Simon A. Gayther, Susan J. Ramus, Usha Menon, Aleksandra Gentry-Maharaj, Joellen M. Schildkraut, Patricia G. MoormanRachel T. Palmieri, Roberta B. Ness, Kirsten Moysich, Daniel W. Cramer, Kathryn L. Terry, Allison F. Vitonis, Malcolm C. Pike, Andrew Berchuck, Celeste Leigh Pearce

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.

Original language	English (US)
Pages (from-to)	40-45
Number of pages	6
Journal	Fertility and sterility
Volume	95
Issue number	1
DOIs	https://doi.org/10.1016/j.fertnstert.2010.06.059
State	Published - Jan 2011

Keywords

Endometriosis
PROGINS
ovarian cancer
progesterone receptor

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2010.06.059

Cite this

Near, A. M., Wu, A. H., Templeman, C., Van Den Berg, D. J., Doherty, J. A., Rossing, M. A., Goode, E. L., Cunningham, J. M., Vierkant, R. A., Fridley, B. L., Chenevix-Trench, G., Webb, P. M., Kjær, S. K., Hogdall, E., Gayther, S. A., Ramus, S. J., Menon, U., Gentry-Maharaj, A., Schildkraut, J. M., ... Pearce, C. L. (2011). Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort. Fertility and sterility, 95(1), 40-45. https://doi.org/10.1016/j.fertnstert.2010.06.059

Progesterone receptor gene polymorphisms and risk of endometriosis : Results from an international collaborative effort. / Near, Aimee M.; Wu, Anna H.; Templeman, Claire; Van Den Berg, David J.; Doherty, Jennifer A.; Rossing, Mary Anne; Goode, Ellen L.; Cunningham, Julie M.; Vierkant, Robert A.; Fridley, Brooke L.; Chenevix-Trench, Georgia; Webb, Penelope M.; Kjær, Susanne Krüger; Hogdall, Estrid; Gayther, Simon A.; Ramus, Susan J.; Menon, Usha; Gentry-Maharaj, Aleksandra; Schildkraut, Joellen M.; Moorman, Patricia G.; Palmieri, Rachel T.; Ness, Roberta B.; Moysich, Kirsten; Cramer, Daniel W.; Terry, Kathryn L.; Vitonis, Allison F.; Pike, Malcolm C.; Berchuck, Andrew; Pearce, Celeste Leigh.

In: Fertility and sterility, Vol. 95, No. 1, 01.2011, p. 40-45.

Research output: Contribution to journal › Article › peer-review

Near, AM, Wu, AH, Templeman, C, Van Den Berg, DJ, Doherty, JA, Rossing, MA, Goode, EL , Cunningham, JM, Vierkant, RA, Fridley, BL, Chenevix-Trench, G, Webb, PM, Kjær, SK, Hogdall, E, Gayther, SA, Ramus, SJ, Menon, U, Gentry-Maharaj, A, Schildkraut, JM, Moorman, PG, Palmieri, RT, Ness, RB, Moysich, K, Cramer, DW, Terry, KL, Vitonis, AF, Pike, MC, Berchuck, A & Pearce, CL 2011, 'Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort', Fertility and sterility, vol. 95, no. 1, pp. 40-45. https://doi.org/10.1016/j.fertnstert.2010.06.059

Near, Aimee M. ; Wu, Anna H. ; Templeman, Claire ; Van Den Berg, David J. ; Doherty, Jennifer A. ; Rossing, Mary Anne ; Goode, Ellen L. ; Cunningham, Julie M. ; Vierkant, Robert A. ; Fridley, Brooke L. ; Chenevix-Trench, Georgia ; Webb, Penelope M. ; Kjær, Susanne Krüger ; Hogdall, Estrid ; Gayther, Simon A. ; Ramus, Susan J. ; Menon, Usha ; Gentry-Maharaj, Aleksandra ; Schildkraut, Joellen M. ; Moorman, Patricia G. ; Palmieri, Rachel T. ; Ness, Roberta B. ; Moysich, Kirsten ; Cramer, Daniel W. ; Terry, Kathryn L. ; Vitonis, Allison F. ; Pike, Malcolm C. ; Berchuck, Andrew ; Pearce, Celeste Leigh. / Progesterone receptor gene polymorphisms and risk of endometriosis : Results from an international collaborative effort. In: Fertility and sterility. 2011 ; Vol. 95, No. 1. pp. 40-45.

@article{db7be65170064fd3a27e2f5c8e916c02,

title = "Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort",

abstract = "Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.",

keywords = "Endometriosis, PROGINS, ovarian cancer, progesterone receptor",

author = "Near, {Aimee M.} and Wu, {Anna H.} and Claire Templeman and {Van Den Berg}, {David J.} and Doherty, {Jennifer A.} and Rossing, {Mary Anne} and Goode, {Ellen L.} and Cunningham, {Julie M.} and Vierkant, {Robert A.} and Fridley, {Brooke L.} and Georgia Chenevix-Trench and Webb, {Penelope M.} and Kj{\ae}r, {Susanne Kr{\"u}ger} and Estrid Hogdall and Gayther, {Simon A.} and Ramus, {Susan J.} and Usha Menon and Aleksandra Gentry-Maharaj and Schildkraut, {Joellen M.} and Moorman, {Patricia G.} and Palmieri, {Rachel T.} and Ness, {Roberta B.} and Kirsten Moysich and Cramer, {Daniel W.} and Terry, {Kathryn L.} and Vitonis, {Allison F.} and Pike, {Malcolm C.} and Andrew Berchuck and Pearce, {Celeste Leigh}",

note = "Funding Information: The Ovarian Cancer Association Consortium is funded by the Ovarian Cancer Research Fund . Financial support was provided by U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729 , the Cancer Council Tasmania and Cancer Foundation of Western Australia (AOCS study) , and the National Health and Medical Research Council (NHMRC) of Australia ( 199600 ) (ACS study). G.C.-T. and P.M.W. are supported by the NHMRC . The Hormones and Ovarian Cancer Prediction Study of Delaware Valley study was supported by grants from the Department of Defense DAMD 17-02-1-0669 and the US National Cancer Institute RO1CA095023 . The work undertaken at Mayo is supported by R01-CA122443. The New England–based Case-Control Study was supported by the US National Cancer Institute grants RO1CA054419 and P50CA105009 . The work undertaken at University College London Hospital/University College London is supported by Cancer Research UK, Medical Research Council, The Eve Appeal, Oak Foundation , and the Department of Health's National Institute of Health Research Biomedical Research Centres funding scheme. The University of Southern California study was supported by the US National Cancer Institute grants P01-CA17054, CA14089, CA61132, CA63464, N01-PC67010, R03-CA113148 ; California Department of Health Services subcontract 050-E8709 ; and California Cancer Research Program grants 00-01389V-20170 and 2110200 . Funding Information: The AOCS Management Group (D. Bowtell, B.V.Sc (Hons), B.A.Sci., Ph.D., Georgia Chenevix-Trench, Ph.D., A. deFazio, Ph.D., D. Gertig, M.B.B.S., Ph.D., A. Green, M.B.B.S., Ph.D., Penelope M. Webb, Ph.D.) gratefully acknowledges the contribution of all the clinical and scientific collaborators (see http://www.aocstudy.org/ ). The ACS Management Group comprises A. Green, M.B.B.S., Ph.D., P. Parsons, Ph.D., N. Hayward, Ph.D., Penelope M. Webb, Ph.D., and D. Whiteman, M.B.B.S., Ph.D. The authors are grateful to the family and friends of Kathryn Sladek Smith for their generous support of OCAC through their donations to the Ovarian Cancer Research Fund . The authors thank all the individuals who took part in these studies and the project staff of all the participating studies.",

year = "2011",

month = jan,

doi = "10.1016/j.fertnstert.2010.06.059",

language = "English (US)",

volume = "95",

pages = "40--45",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Progesterone receptor gene polymorphisms and risk of endometriosis

T2 - Results from an international collaborative effort

AU - Near, Aimee M.

AU - Wu, Anna H.

AU - Templeman, Claire

AU - Van Den Berg, David J.

AU - Doherty, Jennifer A.

AU - Rossing, Mary Anne

AU - Goode, Ellen L.

AU - Cunningham, Julie M.

AU - Vierkant, Robert A.

AU - Fridley, Brooke L.

AU - Chenevix-Trench, Georgia

AU - Webb, Penelope M.

AU - Kjær, Susanne Krüger

AU - Hogdall, Estrid

AU - Gayther, Simon A.

AU - Ramus, Susan J.

AU - Menon, Usha

AU - Gentry-Maharaj, Aleksandra

AU - Schildkraut, Joellen M.

AU - Moorman, Patricia G.

AU - Palmieri, Rachel T.

AU - Ness, Roberta B.

AU - Moysich, Kirsten

AU - Cramer, Daniel W.

AU - Terry, Kathryn L.

AU - Vitonis, Allison F.

AU - Pike, Malcolm C.

AU - Berchuck, Andrew

AU - Pearce, Celeste Leigh

N1 - Funding Information: The Ovarian Cancer Association Consortium is funded by the Ovarian Cancer Research Fund . Financial support was provided by U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729 , the Cancer Council Tasmania and Cancer Foundation of Western Australia (AOCS study) , and the National Health and Medical Research Council (NHMRC) of Australia ( 199600 ) (ACS study). G.C.-T. and P.M.W. are supported by the NHMRC . The Hormones and Ovarian Cancer Prediction Study of Delaware Valley study was supported by grants from the Department of Defense DAMD 17-02-1-0669 and the US National Cancer Institute RO1CA095023 . The work undertaken at Mayo is supported by R01-CA122443. The New England–based Case-Control Study was supported by the US National Cancer Institute grants RO1CA054419 and P50CA105009 . The work undertaken at University College London Hospital/University College London is supported by Cancer Research UK, Medical Research Council, The Eve Appeal, Oak Foundation , and the Department of Health's National Institute of Health Research Biomedical Research Centres funding scheme. The University of Southern California study was supported by the US National Cancer Institute grants P01-CA17054, CA14089, CA61132, CA63464, N01-PC67010, R03-CA113148 ; California Department of Health Services subcontract 050-E8709 ; and California Cancer Research Program grants 00-01389V-20170 and 2110200 . Funding Information: The AOCS Management Group (D. Bowtell, B.V.Sc (Hons), B.A.Sci., Ph.D., Georgia Chenevix-Trench, Ph.D., A. deFazio, Ph.D., D. Gertig, M.B.B.S., Ph.D., A. Green, M.B.B.S., Ph.D., Penelope M. Webb, Ph.D.) gratefully acknowledges the contribution of all the clinical and scientific collaborators (see http://www.aocstudy.org/ ). The ACS Management Group comprises A. Green, M.B.B.S., Ph.D., P. Parsons, Ph.D., N. Hayward, Ph.D., Penelope M. Webb, Ph.D., and D. Whiteman, M.B.B.S., Ph.D. The authors are grateful to the family and friends of Kathryn Sladek Smith for their generous support of OCAC through their donations to the Ovarian Cancer Research Fund . The authors thank all the individuals who took part in these studies and the project staff of all the participating studies.

PY - 2011/1

Y1 - 2011/1

N2 - Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.

AB - Objective: To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele. Design: Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies. Setting: An international ovarian cancer consortium including studies from Australia, Europe, and the United States. Patient(s): Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies. Intervention(s): None. Main Outcome Measure(s): Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis. Result(s): The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio = 0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio = 0.94, 95% confidence interval 0.76-1.16). Conclusion(s): Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.

KW - Endometriosis

KW - PROGINS

KW - ovarian cancer

KW - progesterone receptor

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Progesterone receptor gene polymorphisms and risk of endometriosis: Results from an international collaborative effort

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Keywords

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