Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007

Gordon F. Schwartz; Kevin S. Hughes; Henry T. Lynch; Carol J. Fabian; Ian S. Fentiman; Mark E. Robson; Susan M. Domchek; Lynn C. Hartmann; Roland Holland; David J. Winchester; Benjamin O. Anderson; Banu K. Arun; Harry Bartelink; Philip Bernard; Bernardo Bonanni; Blake Cady; Krishna B. Clough; Stephen A. Feig; Sylvia H. Heywang-Köbrunner; Anthony Howell; Claudine Isaacs; Daniel B. Kopans; Robert E. Mansel; Shahla Masood; Juan P. Palazzo; Peter I. Pressman; Lawrence J. Solin; Michael Untch

doi:10.1111/j.1524-4741.2008.00665.x

Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007

Gordon F. Schwartz, Kevin S. Hughes, Henry T. Lynch, Carol J. Fabian, Ian S. Fentiman, Mark E. Robson, Susan M. Domchek, Lynn C. Hartmann, Roland Holland, David J. Winchester, Benjamin O. Anderson, Banu K. Arun, Harry Bartelink, Philip Bernard, Bernardo Bonanni, Blake Cady, Krishna B. Clough, Stephen A. Feig, Sylvia H. Heywang-Köbrunner, Anthony HowellClaudine Isaacs, Daniel B. Kopans, Robert E. Mansel, Shahla Masood, Juan P. Palazzo, Peter I. Pressman, Lawrence J. Solin, Michael Untch

Medical Oncology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A consensus conference including thirty experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from breast cancer "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference being devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general populations was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazic Jews and other founder groups. Risk reduction strategies for these individuals include surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, i.e., bilateral mastectomy and/or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each of the risk categories. These guidelines for patient care were approved by the entire group of experts.

Original language	English (US)
Pages (from-to)	4-16
Number of pages	13
Journal	Breast Journal
Volume	15
Issue number	1
DOIs	https://doi.org/10.1111/j.1524-4741.2008.00665.x
State	Published - Jan 2009

Keywords

BRCA
Breast cancer
Genetics
Risk

ASJC Scopus subject areas

Internal Medicine
Surgery
Oncology

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10.1111/j.1524-4741.2008.00665.x

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Schwartz, G. F., Hughes, K. S., Lynch, H. T., Fabian, C. J., Fentiman, I. S., Robson, M. E., Domchek, S. M., Hartmann, L. C., Holland, R., Winchester, D. J., Anderson, B. O., Arun, B. K., Bartelink, H., Bernard, P., Bonanni, B., Cady, B., Clough, K. B., Feig, S. A., Heywang-Köbrunner, S. H., ... Untch, M. (2009). Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007. Breast Journal, 15(1), 4-16. https://doi.org/10.1111/j.1524-4741.2008.00665.x

Schwartz, GF, Hughes, KS, Lynch, HT, Fabian, CJ, Fentiman, IS, Robson, ME, Domchek, SM, Hartmann, LC, Holland, R, Winchester, DJ, Anderson, BO, Arun, BK, Bartelink, H, Bernard, P, Bonanni, B, Cady, B, Clough, KB, Feig, SA, Heywang-Köbrunner, SH, Howell, A, Isaacs, C, Kopans, DB, Mansel, RE, Masood, S, Palazzo, JP, Pressman, PI, Solin, LJ & Untch, M 2009, 'Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007', Breast Journal, vol. 15, no. 1, pp. 4-16. https://doi.org/10.1111/j.1524-4741.2008.00665.x

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AU - Isaacs, Claudine

AU - Kopans, Daniel B.

AU - Mansel, Robert E.

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Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007

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Keywords

ASJC Scopus subject areas

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