Primary liver cancer in Alaskan natives 1980–1985

Anne P. Lanier, Brian J. McMahon, Steven R. Alberts, Hans Popper, William L. Heyward

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Abstract

The authors reviewed the cases of 19 Alaskan Natives (15 men, four women) with primary hepatocellular carcinoma (HCC) diagnosed during 1980–1985. Of these 19 patients, 16 were seropositive for hepatitis B surface antigen (HBsAg). Alpha‐fetoprotein (AFP) was elevated in 15 patients (all were HBsAg positive). The patients ranged in age from 8 to 80 years old. Of the 19 patients, 16 were Eskimo, 13 of whom were Yupik. The annual age‐adjusted (world standard) incidence of HCC for all Alaskan Natives was 9.3/100,000 for men and 2.2/100,000 for women. The tumor was resected in seven patients; six showed no recurrence of cancer 1 to 4 years after surgery. Histologic evaluation in 18 patients revealed trabecular type of HCC in 15 and acinar HCC in two others. In 16 specimens in which nontumorous liver could be studied, only six had evidence of cirrhosis; ten others showed variants of chronic persistent hepatitis.

Original languageEnglish (US)
Pages (from-to)1915-1920
Number of pages6
JournalCancer
Volume60
Issue number8
DOIs
StatePublished - Oct 15 1987

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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