Primary central nervous system lymphoma

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Primary central nervous system lymphomas constitute less than 2% of primary brain tumors. Although their cause is unknown, they are in some way related to immunosuppression. The typical patient is a middle-aged man who displays the syndrome of a subacute mass lesion. These tumors most commonly occur as a single, bulky mass in the hemispheric white matter or the deep gray matter, but multiple tumors occur in approximately a fourth of the patients. The findings on computed tomography are distinctive and nearly pathognomonic. The majority of these tumors are B-cell lymphomas with aggressive histologic changes. Surgical intervention should be reserved for tissue diagnosis because surgical removal does not seem to influence the outcome. Conventional therapy consists of whole-brain irradiation with or without chemotherapy. The prognosis for patients with such tumors is grim, the median duration of survival being less than 2 years with conventional therapy and the 5-year survival being less than 5%.

Original languageEnglish (US)
Pages (from-to)1005-1020
Number of pages16
JournalMayo Clinic Proceedings
Volume64
Issue number8
StatePublished - 1989

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Lymphoma
Central Nervous System
Neoplasms
Survival
B-Cell Lymphoma
Brain Neoplasms
Immunosuppression
Tomography
Drug Therapy
Brain
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Primary central nervous system lymphoma. / O'Neill, Brian Patrick; Illig, J. J.

In: Mayo Clinic Proceedings, Vol. 64, No. 8, 1989, p. 1005-1020.

Research output: Contribution to journalArticle

O'Neill, BP & Illig, JJ 1989, 'Primary central nervous system lymphoma', Mayo Clinic Proceedings, vol. 64, no. 8, pp. 1005-1020.
O'Neill, Brian Patrick ; Illig, J. J. / Primary central nervous system lymphoma. In: Mayo Clinic Proceedings. 1989 ; Vol. 64, No. 8. pp. 1005-1020.
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