Prevention of sudden cardiac death beyond the ICD: Have we reached the boundary or are we just burning the surface?

Niyada Naksuk, Christopher V. DeSimone, Suraj Kapa, Samuel J Asirvatham

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Preventing sudden cardiac death (SCD) remains a major unsolved problem in contemporary medical practice. As the most common cause of SCD, treatment for ventricular arrhythmias is the target area of interest in research field. While implantable cardioverter-defibrillator (ICD) effectively decreases death from ventricular arrhythmias in highly selected patients, risk of inappropriate shocks, mortality from frequent therapy, chance of failing in abortion of arrhythmias despite having a defibrillator, and our inability to recognize which of several hundreds of thousands of patients at risk for sudden death but do not meet current criteria for defibrillator, limit ICD effectiveness. In this article, a brief review of mechanism leading to SCD, the existing evidence for a defibrillator and the lacunae in present guidelines for patients clearly at risk for sudden death but without proven benefit from a defibrillator are presented in Section I. Following this, interventional approaches, both catheter-based and general measures that may serve as adjuncts to a defibrillator in preventing this all too common catastrophic end event, are summarized in Section II.

Original languageEnglish (US)
JournalIndian Heart Journal
Volume66
Issue numberSUPPL. 1
DOIs
StatePublished - 2014

Fingerprint

Defibrillators
Implantable Defibrillators
Sudden Cardiac Death
Cardiac Arrhythmias
Sudden Death
Shock
Catheters
Guidelines
Mortality
Therapeutics
Research

Keywords

  • Intracardiac-cardioverter defibrillator
  • Mapping
  • Prevention
  • Sudden cardiac death
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prevention of sudden cardiac death beyond the ICD : Have we reached the boundary or are we just burning the surface? / Naksuk, Niyada; DeSimone, Christopher V.; Kapa, Suraj; Asirvatham, Samuel J.

In: Indian Heart Journal, Vol. 66, No. SUPPL. 1, 2014.

Research output: Contribution to journalArticle

@article{5d358f53f8d74f8cab022ac923b55412,
title = "Prevention of sudden cardiac death beyond the ICD: Have we reached the boundary or are we just burning the surface?",
abstract = "Preventing sudden cardiac death (SCD) remains a major unsolved problem in contemporary medical practice. As the most common cause of SCD, treatment for ventricular arrhythmias is the target area of interest in research field. While implantable cardioverter-defibrillator (ICD) effectively decreases death from ventricular arrhythmias in highly selected patients, risk of inappropriate shocks, mortality from frequent therapy, chance of failing in abortion of arrhythmias despite having a defibrillator, and our inability to recognize which of several hundreds of thousands of patients at risk for sudden death but do not meet current criteria for defibrillator, limit ICD effectiveness. In this article, a brief review of mechanism leading to SCD, the existing evidence for a defibrillator and the lacunae in present guidelines for patients clearly at risk for sudden death but without proven benefit from a defibrillator are presented in Section I. Following this, interventional approaches, both catheter-based and general measures that may serve as adjuncts to a defibrillator in preventing this all too common catastrophic end event, are summarized in Section II.",
keywords = "Intracardiac-cardioverter defibrillator, Mapping, Prevention, Sudden cardiac death, Ventricular tachycardia",
author = "Niyada Naksuk and DeSimone, {Christopher V.} and Suraj Kapa and Asirvatham, {Samuel J}",
year = "2014",
doi = "10.1016/j.ihj.2013.12.046",
language = "English (US)",
volume = "66",
journal = "Indian Heart Journal",
issn = "0019-4832",
publisher = "Cardiology Society of India",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Prevention of sudden cardiac death beyond the ICD

T2 - Have we reached the boundary or are we just burning the surface?

AU - Naksuk, Niyada

AU - DeSimone, Christopher V.

AU - Kapa, Suraj

AU - Asirvatham, Samuel J

PY - 2014

Y1 - 2014

N2 - Preventing sudden cardiac death (SCD) remains a major unsolved problem in contemporary medical practice. As the most common cause of SCD, treatment for ventricular arrhythmias is the target area of interest in research field. While implantable cardioverter-defibrillator (ICD) effectively decreases death from ventricular arrhythmias in highly selected patients, risk of inappropriate shocks, mortality from frequent therapy, chance of failing in abortion of arrhythmias despite having a defibrillator, and our inability to recognize which of several hundreds of thousands of patients at risk for sudden death but do not meet current criteria for defibrillator, limit ICD effectiveness. In this article, a brief review of mechanism leading to SCD, the existing evidence for a defibrillator and the lacunae in present guidelines for patients clearly at risk for sudden death but without proven benefit from a defibrillator are presented in Section I. Following this, interventional approaches, both catheter-based and general measures that may serve as adjuncts to a defibrillator in preventing this all too common catastrophic end event, are summarized in Section II.

AB - Preventing sudden cardiac death (SCD) remains a major unsolved problem in contemporary medical practice. As the most common cause of SCD, treatment for ventricular arrhythmias is the target area of interest in research field. While implantable cardioverter-defibrillator (ICD) effectively decreases death from ventricular arrhythmias in highly selected patients, risk of inappropriate shocks, mortality from frequent therapy, chance of failing in abortion of arrhythmias despite having a defibrillator, and our inability to recognize which of several hundreds of thousands of patients at risk for sudden death but do not meet current criteria for defibrillator, limit ICD effectiveness. In this article, a brief review of mechanism leading to SCD, the existing evidence for a defibrillator and the lacunae in present guidelines for patients clearly at risk for sudden death but without proven benefit from a defibrillator are presented in Section I. Following this, interventional approaches, both catheter-based and general measures that may serve as adjuncts to a defibrillator in preventing this all too common catastrophic end event, are summarized in Section II.

KW - Intracardiac-cardioverter defibrillator

KW - Mapping

KW - Prevention

KW - Sudden cardiac death

KW - Ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=84896727981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896727981&partnerID=8YFLogxK

U2 - 10.1016/j.ihj.2013.12.046

DO - 10.1016/j.ihj.2013.12.046

M3 - Article

C2 - 24568823

AN - SCOPUS:84896727981

VL - 66

JO - Indian Heart Journal

JF - Indian Heart Journal

SN - 0019-4832

IS - SUPPL. 1

ER -