Prevalence of GBA p.K198E mutation in Colombian and Hispanic populations

Philip W. Tipton, Alexandra I. Soto-Beasley, Ronald L. Walton, Silvia Soler-Rangel, Óscar Romero-Osorio, Cindy Díaz, Claudia Lucía Moreno-López, Owen A. Ross, Zbigniew K. Wszolek, Catalina Cerquera-Cleves

Research output: Contribution to journalLetter

Abstract

We aimed to replicate a recent study that found a high frequency of the GBA p.K198E mutant in Colombian patients with PD. We identified the p.K198E substitution at a lower frequency in our cohort of Colombians with PD (2.1%), and this was not significantly different than controls (1.7%, P = 0.86) emphasizing the need for larger genetic studies in Latin America.

Original languageEnglish (US)
Pages (from-to)16-18
Number of pages3
JournalParkinsonism and Related Disorders
Volume73
DOIs
StatePublished - Apr 2020

Keywords

  • GBA
  • Gaucher's disease
  • Genetics
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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  • Cite this

    Tipton, P. W., Soto-Beasley, A. I., Walton, R. L., Soler-Rangel, S., Romero-Osorio, Ó., Díaz, C., Moreno-López, C. L., Ross, O. A., Wszolek, Z. K., & Cerquera-Cleves, C. (2020). Prevalence of GBA p.K198E mutation in Colombian and Hispanic populations. Parkinsonism and Related Disorders, 73, 16-18. https://doi.org/10.1016/j.parkreldis.2020.03.008