Prevalence of GBA p.K198E mutation in Colombian and Hispanic populations

Philip W. Tipton, Alexandra I. Soto-Beasley, Ronald L. Walton, Silvia Soler-Rangel, Óscar Romero-Osorio, Cindy Díaz, Claudia Lucía Moreno-López, Owen A. Ross, Zbigniew K. Wszolek, Catalina Cerquera-Cleves

Research output: Contribution to journalLetterpeer-review

Abstract

We aimed to replicate a recent study that found a high frequency of the GBA p.K198E mutant in Colombian patients with PD. We identified the p.K198E substitution at a lower frequency in our cohort of Colombians with PD (2.1%), and this was not significantly different than controls (1.7%, P = 0.86) emphasizing the need for larger genetic studies in Latin America.

Original languageEnglish (US)
Pages (from-to)16-18
Number of pages3
JournalParkinsonism and Related Disorders
Volume73
DOIs
StatePublished - Apr 2020

Keywords

  • GBA
  • Gaucher's disease
  • Genetics
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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