TY - JOUR
T1 - Prevalence of aspirin resistance by thromboelastography plus platelet mapping in children with CHD
T2 - A single-centre experience
AU - Berganza, Fernando M.
AU - Gonzalez De Alba, Cesar
AU - Egbe, Alexander C.
AU - Bartakian, Sergio
AU - Brownlee, John
N1 - Publisher Copyright:
© Cambridge University Press 2018.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Rationale Aspirin resistance has been reported in up to 80% of children with cardiovascular defects undergoing surgery. Because of a patient who had embolic stroke while on therapeutic aspirin dose but in whom aspirin resistance was present on his thromboelastography platelet mapping, we chose to obtain thromboelastography platelet mapping on cardiac patients on aspirin to assess their risk.Objectives This study evaluates aspirin resistance noted in these patients and their characteristics.Methods and results This is a retrospective study of 25 patients taking aspirin for a month at therapeutic dose. In total, 11 female patients were enrolled. Ages in all subjects were 5 months to 27 years. A total of 19 patients had a Fontan surgery. Three had a cavopulomanary anastomosis, one had a hybrid procedure, and two had coronary anomalies. Compliance was assessed at the time of the clinic visit. Aspirin resistance was defined as platelet inhibition below 50%. Variables evaluated were level of platelet inhibition, age, body mass index, and gender.
AB - Rationale Aspirin resistance has been reported in up to 80% of children with cardiovascular defects undergoing surgery. Because of a patient who had embolic stroke while on therapeutic aspirin dose but in whom aspirin resistance was present on his thromboelastography platelet mapping, we chose to obtain thromboelastography platelet mapping on cardiac patients on aspirin to assess their risk.Objectives This study evaluates aspirin resistance noted in these patients and their characteristics.Methods and results This is a retrospective study of 25 patients taking aspirin for a month at therapeutic dose. In total, 11 female patients were enrolled. Ages in all subjects were 5 months to 27 years. A total of 19 patients had a Fontan surgery. Three had a cavopulomanary anastomosis, one had a hybrid procedure, and two had coronary anomalies. Compliance was assessed at the time of the clinic visit. Aspirin resistance was defined as platelet inhibition below 50%. Variables evaluated were level of platelet inhibition, age, body mass index, and gender.
KW - CHD
KW - Key wordsAspirin resistance
KW - general cardiology
KW - platelet mapping
KW - thromboelastography
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U2 - 10.1017/S1047951118000021
DO - 10.1017/S1047951118000021
M3 - Article
C2 - 30501653
AN - SCOPUS:85057577629
SN - 1047-9511
VL - 29
SP - 24
EP - 29
JO - Cardiology in the young
JF - Cardiology in the young
IS - 1
ER -