Pretransplantation Exercise and Hematopoietic Cell Transplantation Survival: A Secondary Analysis of Blood and Marrow Transplant Clinical Trials Network (BMT CTN 0902)

John R. Wingard, William A. Wood, Michael Martens, Jennifer Le-Rademacher, Brent Logan, Jennifer M. Knight, Paul B. Jacobsen, Heather Jim, Navneet S. Majhail, Karen Syrjala, J. Douglas Rizzo, Stephanie J. Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Blood and Marrow Transplant Clinical Trials Network (BMT CTN) protocol 0902 evaluated whether exercise and stress management training before hematopoietic cell transplantation (HCT) improved physical and mental functioning after HCT. Neither overall survival nor other patient-reported transplantation outcomes were improved by the training intervention. In some animal studies of HCT, moderate-intensity exercise for 8 weeks before HCT has been associated with positive effects on hematopoietic progenitors, resulting in improved donor engraftment and improved survival. Accordingly, we performed a secondary analysis of data from BMT CTN 0902 to determine whether exercise engagement before HCT was associated with engraftment and survival. We found no significant associations between self-reported pre-HCT exercise levels and engraftment or survival. There was also no effect of pretransplantation exercise on either neutrophil or platelet engraftment. These findings do not support the observations in animal models but are limited by several shortcomings that do not refute the hypothesis that exercise before HCT may be beneficial.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalBiology of Blood and Marrow Transplantation
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2017

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Cell Transplantation
Cell Survival
Bone Marrow
Clinical Trials
Transplants
Clinical Protocols
Neutrophils
Blood Platelets
Animal Models
Transplantation

Keywords

  • Allogeneic
  • Exercise
  • Hematopoietic
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Pretransplantation Exercise and Hematopoietic Cell Transplantation Survival : A Secondary Analysis of Blood and Marrow Transplant Clinical Trials Network (BMT CTN 0902). / Wingard, John R.; Wood, William A.; Martens, Michael; Le-Rademacher, Jennifer; Logan, Brent; Knight, Jennifer M.; Jacobsen, Paul B.; Jim, Heather; Majhail, Navneet S.; Syrjala, Karen; Rizzo, J. Douglas; Lee, Stephanie J.

In: Biology of Blood and Marrow Transplantation, Vol. 23, No. 1, 01.01.2017, p. 161-164.

Research output: Contribution to journalArticle

Wingard, John R. ; Wood, William A. ; Martens, Michael ; Le-Rademacher, Jennifer ; Logan, Brent ; Knight, Jennifer M. ; Jacobsen, Paul B. ; Jim, Heather ; Majhail, Navneet S. ; Syrjala, Karen ; Rizzo, J. Douglas ; Lee, Stephanie J. / Pretransplantation Exercise and Hematopoietic Cell Transplantation Survival : A Secondary Analysis of Blood and Marrow Transplant Clinical Trials Network (BMT CTN 0902). In: Biology of Blood and Marrow Transplantation. 2017 ; Vol. 23, No. 1. pp. 161-164.
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