Prenatal symmetrical thalamic degeneration with flexion spasticity at birth

Joseph E Parisi, G. H. Collins, R. C. Kim, C. J. Crosly

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The unusual occurrence of spasticity at birth with symmetrical thalamic damage was found in a male infant delivered at 36 weeks' gestation following an episode of traumatically induced premature labor at 32 weeks. The infant was found to be spastic in flexion with increased stretch reflexes, depressed primitive reflexes, and moderate flexion contractures. Computerized tomographic scans showed bilateral nonenhancing thalamic densities. Neuropathologically, the lateral thalamic nuclei and the red nucleus showed neuron loss, astrocytosis, and, as confirmed by electron microprobe analysis, calcified neurons. The striatum was uninvolved. These findings closely resemble those reported as 'symmetrical thalamic degeneration in infancy' and are strongly reminiscent of the pattern of thalamic involvement frequently seen in status marmoratus. It would appear that there is a period during perinatal life in which the lateral thalamus can be rendered vulnerable to hypoxic-ischemic injury, and that the thirty-second week of gestation must be included within this period.

Original languageEnglish (US)
Pages (from-to)94-97
Number of pages4
JournalAnnals of Neurology
Volume13
Issue number1
StatePublished - 1983
Externally publishedYes

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Parturition
Induced Labor
Red Nucleus
Lateral Thalamic Nuclei
Neurons
Stretch Reflex
Pregnancy
Gliosis
Muscle Spasticity
Premature Obstetric Labor
Movement Disorders
Contracture
Thalamus
Reflex
Electrons
Wounds and Injuries

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Parisi, J. E., Collins, G. H., Kim, R. C., & Crosly, C. J. (1983). Prenatal symmetrical thalamic degeneration with flexion spasticity at birth. Annals of Neurology, 13(1), 94-97.

Prenatal symmetrical thalamic degeneration with flexion spasticity at birth. / Parisi, Joseph E; Collins, G. H.; Kim, R. C.; Crosly, C. J.

In: Annals of Neurology, Vol. 13, No. 1, 1983, p. 94-97.

Research output: Contribution to journalArticle

Parisi, JE, Collins, GH, Kim, RC & Crosly, CJ 1983, 'Prenatal symmetrical thalamic degeneration with flexion spasticity at birth', Annals of Neurology, vol. 13, no. 1, pp. 94-97.
Parisi JE, Collins GH, Kim RC, Crosly CJ. Prenatal symmetrical thalamic degeneration with flexion spasticity at birth. Annals of Neurology. 1983;13(1):94-97.
Parisi, Joseph E ; Collins, G. H. ; Kim, R. C. ; Crosly, C. J. / Prenatal symmetrical thalamic degeneration with flexion spasticity at birth. In: Annals of Neurology. 1983 ; Vol. 13, No. 1. pp. 94-97.
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