TY - JOUR
T1 - Prenatal diagnosis and perinatal outcomes of congenital megalourethra
T2 - A multicenter cohort study and systematic review of the literature
AU - Moaddab, Amirhossein
AU - Sananes, Nicolas
AU - Hernandez-Ruano, Simone
AU - Britto, Ingrid Schwach Werneck
AU - Blumenfeld, Yair
AU - Stoll, François
AU - Favre, Romain
AU - Ruano, Rodrigo
N1 - Publisher Copyright:
© 2015 by the American Institute of Ultrasound in Medicine.
PY - 2015/11
Y1 - 2015/11
N2 - Objectives-The purpose of this study was to evaluate the prenatal findings and postnatal outcomes in fetuses with congenital megalourethra. Methods-This retrospective study reviewed our experience and the literature between 1989 and 2014. Prenatal findings were evaluated and compared with postnatal findings, including neonatal mortality and abnormal renal function (need for dialysis or renal transplantation). Results-Fifty fetuses with congenital megalourethra were analyzed, including 6 cases diagnosed in our centers. Most cases (n = 43 [86.0%]) were diagnosed in the second trimester. Only 1 case was diagnosed in the first trimester, whereas 6 cases (12.0%) were diagnosed in the third trimester. Thirty-five fetuses (70.0%) survived. Bilateral hydro - ureters were associated with perinatal death (P= .024). Among the survivors, 41.9% of the neonates had renal impairment. The following factors were associated with postnatal renal impairment: presence of severe oligohydramnios/anhydramnios (P = .033), bilateral hydronephrosis (P = .008), and earlier gestational age at delivery (P = .022). Conclusions-In fetal megalourethra, bilateral hydroureters, bilateral hydronephrosis, and severe oligohydramnios/anhydramnios are associated with neonatal mortality and renal impairment.
AB - Objectives-The purpose of this study was to evaluate the prenatal findings and postnatal outcomes in fetuses with congenital megalourethra. Methods-This retrospective study reviewed our experience and the literature between 1989 and 2014. Prenatal findings were evaluated and compared with postnatal findings, including neonatal mortality and abnormal renal function (need for dialysis or renal transplantation). Results-Fifty fetuses with congenital megalourethra were analyzed, including 6 cases diagnosed in our centers. Most cases (n = 43 [86.0%]) were diagnosed in the second trimester. Only 1 case was diagnosed in the first trimester, whereas 6 cases (12.0%) were diagnosed in the third trimester. Thirty-five fetuses (70.0%) survived. Bilateral hydro - ureters were associated with perinatal death (P= .024). Among the survivors, 41.9% of the neonates had renal impairment. The following factors were associated with postnatal renal impairment: presence of severe oligohydramnios/anhydramnios (P = .033), bilateral hydronephrosis (P = .008), and earlier gestational age at delivery (P = .022). Conclusions-In fetal megalourethra, bilateral hydroureters, bilateral hydronephrosis, and severe oligohydramnios/anhydramnios are associated with neonatal mortality and renal impairment.
KW - Anterior urethral valves
KW - Congenital megalourethra
KW - Fetal surgery
KW - Lower urinary tract obstruction
KW - Obstetric ultrasound
KW - Posterior urethral valves
KW - Urethral atresia
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U2 - 10.7863/ultra.14.12064
DO - 10.7863/ultra.14.12064
M3 - Review article
C2 - 26446816
AN - SCOPUS:84944891148
SN - 0278-4297
VL - 34
SP - 2057
EP - 2064
JO - Journal of Ultrasound in Medicine
JF - Journal of Ultrasound in Medicine
IS - 11
ER -