Prenatal diagnosis and perinatal outcomes of congenital megalourethra: A multicenter cohort study and systematic review of the literature

Amirhossein Moaddab, Nicolas Sananes, Simone Hernandez-Ruano, Ingrid Schwach Werneck Britto, Yair Blumenfeld, François Stoll, Romain Favre, Rodrigo Ruano

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Objectives-The purpose of this study was to evaluate the prenatal findings and postnatal outcomes in fetuses with congenital megalourethra. Methods-This retrospective study reviewed our experience and the literature between 1989 and 2014. Prenatal findings were evaluated and compared with postnatal findings, including neonatal mortality and abnormal renal function (need for dialysis or renal transplantation). Results-Fifty fetuses with congenital megalourethra were analyzed, including 6 cases diagnosed in our centers. Most cases (n = 43 [86.0%]) were diagnosed in the second trimester. Only 1 case was diagnosed in the first trimester, whereas 6 cases (12.0%) were diagnosed in the third trimester. Thirty-five fetuses (70.0%) survived. Bilateral hydro - ureters were associated with perinatal death (P= .024). Among the survivors, 41.9% of the neonates had renal impairment. The following factors were associated with postnatal renal impairment: presence of severe oligohydramnios/anhydramnios (P = .033), bilateral hydronephrosis (P = .008), and earlier gestational age at delivery (P = .022). Conclusions-In fetal megalourethra, bilateral hydroureters, bilateral hydronephrosis, and severe oligohydramnios/anhydramnios are associated with neonatal mortality and renal impairment.

Original languageEnglish (US)
Pages (from-to)2057-2064
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume34
Issue number11
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Anterior urethral valves
  • Congenital megalourethra
  • Fetal surgery
  • Lower urinary tract obstruction
  • Obstetric ultrasound
  • Posterior urethral valves
  • Urethral atresia

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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