Pregnancy-associated plasma protein-A expression in human breast cancer

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13 Citations (Scopus)

Abstract

Objective: Pregnancy-associated plasma protein-A (PAPP-A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. PAPP-A has been implicated in several cancers. However, studies of PAPP-A expression in breast cancer are limited. In this study, we assessed PAPP-A expression in different subtypes of human malignant breast cancer.Design Formalin-fixed paraffin-embedded tumor samples from 46 female patients with invasive breast cancer were divided into five defined groups [using markers for HER2, estrogen receptor, progesterone receptor, proliferation] that roughly correlate with molecularly defined subtypes (luminal A, luminal B, luminal/HER2. +, HER2. +, triple negative). These samples were analyzed for PAPP-A expression by immunohistochemistry. Results: PAPP-A staining in tumor tissue was detected in 45 of 46 specimens. There were significantly greater extent and intensity of PAPP-A expression in luminal B specimens with high proliferation index than luminal A specimens (. P=. 0.01). However, there were no differences between specimens positive or negative for HER2 (. P=. 0.14) or positive and negative for estrogen receptor (. P=. 0.31). Conclusion: PAPP-A was detected in almost all breast cancer specimens and a more intense and greater extent of its expression was associated with luminal B specimens compared to luminal A specimens. The role of PAPP-A in breast cancer prognosis, and possibly therapeutics, warrants further investigation.

Original languageEnglish (US)
Pages (from-to)264-267
Number of pages4
JournalGrowth Hormone and IGF Research
Volume24
Issue number6
DOIs
StatePublished - Dec 1 2014

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Pregnancy-Associated Plasma Protein-A
Breast Neoplasms
Estrogen Receptors
Neoplasms
Metalloproteases
Somatomedins
Progesterone Receptors
Paraffin
Formaldehyde
Zinc
Immunohistochemistry
Staining and Labeling

Keywords

  • Breast cancer
  • Immunohistochemistry
  • Pregnancy-associated plasma protein-A

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{562f78229603482881dcbd5fb0d7baa8,
title = "Pregnancy-associated plasma protein-A expression in human breast cancer",
abstract = "Objective: Pregnancy-associated plasma protein-A (PAPP-A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. PAPP-A has been implicated in several cancers. However, studies of PAPP-A expression in breast cancer are limited. In this study, we assessed PAPP-A expression in different subtypes of human malignant breast cancer.Design Formalin-fixed paraffin-embedded tumor samples from 46 female patients with invasive breast cancer were divided into five defined groups [using markers for HER2, estrogen receptor, progesterone receptor, proliferation] that roughly correlate with molecularly defined subtypes (luminal A, luminal B, luminal/HER2. +, HER2. +, triple negative). These samples were analyzed for PAPP-A expression by immunohistochemistry. Results: PAPP-A staining in tumor tissue was detected in 45 of 46 specimens. There were significantly greater extent and intensity of PAPP-A expression in luminal B specimens with high proliferation index than luminal A specimens (. P=. 0.01). However, there were no differences between specimens positive or negative for HER2 (. P=. 0.14) or positive and negative for estrogen receptor (. P=. 0.31). Conclusion: PAPP-A was detected in almost all breast cancer specimens and a more intense and greater extent of its expression was associated with luminal B specimens compared to luminal A specimens. The role of PAPP-A in breast cancer prognosis, and possibly therapeutics, warrants further investigation.",
keywords = "Breast cancer, Immunohistochemistry, Pregnancy-associated plasma protein-A",
author = "Aaron Mansfield and Visscher, {Daniel W} and Steven Hart and Chen Wang and Goetz, {Matthew Philip} and Claus Oxvig and Conover, {Cheryl A}",
year = "2014",
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doi = "10.1016/j.ghir.2014.10.007",
language = "English (US)",
volume = "24",
pages = "264--267",
journal = "Endocrinology and Metabolism, Supplement",
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TY - JOUR

T1 - Pregnancy-associated plasma protein-A expression in human breast cancer

AU - Mansfield, Aaron

AU - Visscher, Daniel W

AU - Hart, Steven

AU - Wang, Chen

AU - Goetz, Matthew Philip

AU - Oxvig, Claus

AU - Conover, Cheryl A

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Objective: Pregnancy-associated plasma protein-A (PAPP-A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. PAPP-A has been implicated in several cancers. However, studies of PAPP-A expression in breast cancer are limited. In this study, we assessed PAPP-A expression in different subtypes of human malignant breast cancer.Design Formalin-fixed paraffin-embedded tumor samples from 46 female patients with invasive breast cancer were divided into five defined groups [using markers for HER2, estrogen receptor, progesterone receptor, proliferation] that roughly correlate with molecularly defined subtypes (luminal A, luminal B, luminal/HER2. +, HER2. +, triple negative). These samples were analyzed for PAPP-A expression by immunohistochemistry. Results: PAPP-A staining in tumor tissue was detected in 45 of 46 specimens. There were significantly greater extent and intensity of PAPP-A expression in luminal B specimens with high proliferation index than luminal A specimens (. P=. 0.01). However, there were no differences between specimens positive or negative for HER2 (. P=. 0.14) or positive and negative for estrogen receptor (. P=. 0.31). Conclusion: PAPP-A was detected in almost all breast cancer specimens and a more intense and greater extent of its expression was associated with luminal B specimens compared to luminal A specimens. The role of PAPP-A in breast cancer prognosis, and possibly therapeutics, warrants further investigation.

AB - Objective: Pregnancy-associated plasma protein-A (PAPP-A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. PAPP-A has been implicated in several cancers. However, studies of PAPP-A expression in breast cancer are limited. In this study, we assessed PAPP-A expression in different subtypes of human malignant breast cancer.Design Formalin-fixed paraffin-embedded tumor samples from 46 female patients with invasive breast cancer were divided into five defined groups [using markers for HER2, estrogen receptor, progesterone receptor, proliferation] that roughly correlate with molecularly defined subtypes (luminal A, luminal B, luminal/HER2. +, HER2. +, triple negative). These samples were analyzed for PAPP-A expression by immunohistochemistry. Results: PAPP-A staining in tumor tissue was detected in 45 of 46 specimens. There were significantly greater extent and intensity of PAPP-A expression in luminal B specimens with high proliferation index than luminal A specimens (. P=. 0.01). However, there were no differences between specimens positive or negative for HER2 (. P=. 0.14) or positive and negative for estrogen receptor (. P=. 0.31). Conclusion: PAPP-A was detected in almost all breast cancer specimens and a more intense and greater extent of its expression was associated with luminal B specimens compared to luminal A specimens. The role of PAPP-A in breast cancer prognosis, and possibly therapeutics, warrants further investigation.

KW - Breast cancer

KW - Immunohistochemistry

KW - Pregnancy-associated plasma protein-A

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JO - Endocrinology and Metabolism, Supplement

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