Pregnancy: a clue to normal regulation of B lymphopoiesis

Paul W. Kincade; Kay L. Medina; Glennda Smithson; Denise C. Scott

doi:10.1016/0167-5699(94)90211-9

Pregnancy: a clue to normal regulation of B lymphopoiesis

Paul W. Kincade, Kay L. Medina, Glennda Smithson, Denise C. Scott

Immunology

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47 Scopus citations

Abstract

The large-scale production of lymphocytes in the bone marrow reflects a delicate balance between positive and negative regulatory signals. For instance, interleukin 7 (IL-7) provides a positive signal, and appears to be both essential and limiting in the mouse. However, much less is understood concerning the negative molecular signals that may limit the output of lymphocytes. Here, Paul Kincade and colleagues discuss how a chance observation with pregnant mice revealed that sex steroids can act as negative regulators of B lymphopoiesis, and may do so under normal steady-state conditions.

Original language	English (US)
Pages (from-to)	539-544
Number of pages	6
Journal	Immunology Today
Volume	15
Issue number	11
DOIs	https://doi.org/10.1016/0167-5699(94)90211-9
State	Published - Nov 1994

ASJC Scopus subject areas

Immunology

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10.1016/0167-5699(94)90211-9

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title = "Pregnancy: a clue to normal regulation of B lymphopoiesis",

abstract = "The large-scale production of lymphocytes in the bone marrow reflects a delicate balance between positive and negative regulatory signals. For instance, interleukin 7 (IL-7) provides a positive signal, and appears to be both essential and limiting in the mouse. However, much less is understood concerning the negative molecular signals that may limit the output of lymphocytes. Here, Paul Kincade and colleagues discuss how a chance observation with pregnant mice revealed that sex steroids can act as negative regulators of B lymphopoiesis, and may do so under normal steady-state conditions.",

author = "Kincade, {Paul W.} and Medina, {Kay L.} and Glennda Smithson and Scott, {Denise C.}",

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T2 - a clue to normal regulation of B lymphopoiesis

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AU - Medina, Kay L.

AU - Smithson, Glennda

AU - Scott, Denise C.

PY - 1994/11

Y1 - 1994/11

N2 - The large-scale production of lymphocytes in the bone marrow reflects a delicate balance between positive and negative regulatory signals. For instance, interleukin 7 (IL-7) provides a positive signal, and appears to be both essential and limiting in the mouse. However, much less is understood concerning the negative molecular signals that may limit the output of lymphocytes. Here, Paul Kincade and colleagues discuss how a chance observation with pregnant mice revealed that sex steroids can act as negative regulators of B lymphopoiesis, and may do so under normal steady-state conditions.

AB - The large-scale production of lymphocytes in the bone marrow reflects a delicate balance between positive and negative regulatory signals. For instance, interleukin 7 (IL-7) provides a positive signal, and appears to be both essential and limiting in the mouse. However, much less is understood concerning the negative molecular signals that may limit the output of lymphocytes. Here, Paul Kincade and colleagues discuss how a chance observation with pregnant mice revealed that sex steroids can act as negative regulators of B lymphopoiesis, and may do so under normal steady-state conditions.

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Pregnancy: a clue to normal regulation of B lymphopoiesis

Abstract

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