Predictors of patient and graft survival following liver transplantation for hepatitis C

Michael Charlton, Eric Seaberg, Russell Wiesner, James Everhart, Rowen Zetterman, John Lake, Katherine Detre, Jay Hoofnagle

Research output: Contribution to journalArticle

495 Scopus citations

Abstract

End-stage liver disease secondary to hepatitis C virus (HCV) infection is the leading indication for liver transplantation in the United States. Recurrence of HCV infection is nearly universal. We studied the patients enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database to determine whether pretransplantation patient or donor variables could identify a subset of HCV- infected recipients with poor patient survival. Between April 15, 1990, and June 30, 1994, 166 HCV-infected and 509 HCV-negative patients underwent liver transplantation at the participating institutions. Median follow-up was 5.0 years for HCV-infected and 5.2 years for HCV-negative recipients. Pretransplantation donor and recipient characteristics, and patient and graft survival, were prospectively collected and compared. Cumulative patient survival for HCV-infected recipients was similar to that of recipients transplanted for chronic nonB-C hepatitis, or alcoholic and metabolic liver disease, better than that of patients transplanted for malignancy or hepatitis B (P = .02 and P = .003, respectively), and significantly worse than that of patients transplanted for cholestatic liver disease (P = .001). Recipients who had a pretransplantation HCV-RNA titer of ≤ 1 x 106 vEq/mL had a cumulative 5-year survival of 57% versus 84% for those with HCV-RNA titers of <1 x 106 vEq/mL (P = .0001). Patient and graft survival did not vary with recipient gender, HCV genotype, or induction immunosuppression regimen among the HCV-infected recipients. While long-term patient and graft survival following liver transplantation for end-stage liver disease secondary to HCV are generally comparable with that of most other indications, higher pretransplantation HCV-RNA titers are strongly associated with poor survival among HCV-infected recipients.

Original languageEnglish (US)
Pages (from-to)823-830
Number of pages8
JournalHepatology
Volume28
Issue number3
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'Predictors of patient and graft survival following liver transplantation for hepatitis C'. Together they form a unique fingerprint.

  • Cite this

    Charlton, M., Seaberg, E., Wiesner, R., Everhart, J., Zetterman, R., Lake, J., Detre, K., & Hoofnagle, J. (1998). Predictors of patient and graft survival following liver transplantation for hepatitis C. Hepatology, 28(3), 823-830. https://doi.org/10.1002/hep.510280333