Predictive factors for local control and survival in patients with cancer of unknown primary (CUP) irradiated for cerebral metastases

Dirk Rades, Liesa Dziggel, Stefan Janssen, Mai Trong Khoa, Vuong Ngoc Duong, Vu Huu Khiem, Niklas Gebauer, Tobias Bartscht, Steven E. Schild

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background/Aim: To identify predictors of local control and survival after whole-brain irradiation (WBI) for cerebral metastases from cancer of unknown primary (CUP). Patients and Methods: In 140 patients receiving WBI alone or following resection, seven factors were investigated including treatment approach, WBI-regimen, age, gender, Eastern Cooperative Oncology Group (ECOG) performance score, number of cerebral lesions and extra-cerebral metastases. Results: On univariate analysis, resection plus WBI and boost (p=0.002), ECOG 0-1 (p<0.001) and a single lesion (p<0.001) were positively associated with local control. On Cox regression, ECOG-score remained significant (p=0.002). On univariate analysis of survival, surgery plus WBI and boost (p=0.009), ECOG 0-1 (p<0.001), a single lesion (p=0.024) and no extra-cerebral metastases (p<0.001) were associated with better outcomes. On Cox regression, ECOG-score (p<0.001) and extra-cerebral lesions (p<0.001) were significant. Conclusion: Significant predictors of local control and survival were identified that contribute to treatment personalization and design of prospective trials in patients with cerebral metastases from CUP.

Original languageEnglish (US)
Pages (from-to)2415-2418
Number of pages4
JournalAnticancer Research
Volume38
Issue number4
DOIs
StatePublished - Apr 1 2018

Keywords

  • Cancer of unknown primary (CUP)
  • Cerebral metastasis
  • Local control
  • Prognoses
  • Survival
  • Whole-brain irradiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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