Prediction of mortality in community-living frail elderly people with long-term care needs

Elise Carey, Kenneth E. Covinsky, Li Yung Lui, Catherine Eng, Laura P. Sands, Louise C. Walter

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

OBJECTIVES: To develop and validate a prognostic index for mortality in community-living, frail elderly people. DESIGN: Cohort study of Program of All-Inclusive Care for the Elderly (PACE) participants enrolled between 1988 and 1996. SETTING: Eleven PACE sites, a community-based long-term care program that cares for frail, chronically ill elderly people who meet criteria for nursing home placement. PARTICIPANTS: Three thousand eight hundred ninety-nine PACE enrollees. The index was developed in 2,232 participants and validated in 1,667. MEASUREMENTS: Time to death was predicted using risk factors obtained from a geriatric assessment performed by the PACE interdisciplinary team at the time of enrollment. Risk factors included demographic characteristics, comorbid conditions, and functional status. RESULTS: The development cohort had a mean age of 79 (68% female, 40% white). The validation cohort had a mean age of 79 (76% female, 65% white). In the development cohort, eight independent risk factors of mortality were identified and weighted, using Cox regression, to create a risk score: male sex, 2 points; age (75-79, 2 points; 80-84, 2 points; ≥85, 3 points); dependence in toileting, 1 point; dependence in dressing (partial dependence, 1 point; full dependence, 3 points); malignant neoplasm, 2 points; congestive heart failure, 3 points; chronic obstructive pulmonary disease, 1 point; and renal insufficiency, 3 points. In the development cohort, respective 1- and 3-year mortality rates were 6% and 21% in the lowest-risk group (0-3 points), 12% and 36% in the middle-risk group (4-5 points), and 21% and 54% in the highest-risk group (>5 points). In the validation cohort, respective 1- and 3-year mortality rates were 7% and 18% in the lowest-risk group, 11% and 36% in the middle-risk group, and 22% and 55% in the highest-risk group. The area under the receiver operating characteristic curve for the point score was 0.66 and 0.69 in the development and validation cohorts, respectively. CONCLUSION: A multidimensional prognostic index was developed and validated using age, sex, functional status, and comorbidities that effectively stratifies frail, community-living elderly people into groups at varying risk of mortality.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalJournal of the American Geriatrics Society
Volume56
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Frail Elderly
Long-Term Care
Mortality
Geriatric Assessment
Bandages
Nursing Homes
ROC Curve
Chronic Obstructive Pulmonary Disease
Renal Insufficiency
Comorbidity
Chronic Disease
Cohort Studies
Heart Failure
Demography

Keywords

  • Aging
  • Frailty
  • Functional impairment
  • Long-term care
  • Mortality
  • Palliative care

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Prediction of mortality in community-living frail elderly people with long-term care needs. / Carey, Elise; Covinsky, Kenneth E.; Lui, Li Yung; Eng, Catherine; Sands, Laura P.; Walter, Louise C.

In: Journal of the American Geriatrics Society, Vol. 56, No. 1, 01.01.2008, p. 68-75.

Research output: Contribution to journalArticle

Carey, Elise ; Covinsky, Kenneth E. ; Lui, Li Yung ; Eng, Catherine ; Sands, Laura P. ; Walter, Louise C. / Prediction of mortality in community-living frail elderly people with long-term care needs. In: Journal of the American Geriatrics Society. 2008 ; Vol. 56, No. 1. pp. 68-75.
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AU - Covinsky, Kenneth E.

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AU - Sands, Laura P.

AU - Walter, Louise C.

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N2 - OBJECTIVES: To develop and validate a prognostic index for mortality in community-living, frail elderly people. DESIGN: Cohort study of Program of All-Inclusive Care for the Elderly (PACE) participants enrolled between 1988 and 1996. SETTING: Eleven PACE sites, a community-based long-term care program that cares for frail, chronically ill elderly people who meet criteria for nursing home placement. PARTICIPANTS: Three thousand eight hundred ninety-nine PACE enrollees. The index was developed in 2,232 participants and validated in 1,667. MEASUREMENTS: Time to death was predicted using risk factors obtained from a geriatric assessment performed by the PACE interdisciplinary team at the time of enrollment. Risk factors included demographic characteristics, comorbid conditions, and functional status. RESULTS: The development cohort had a mean age of 79 (68% female, 40% white). The validation cohort had a mean age of 79 (76% female, 65% white). In the development cohort, eight independent risk factors of mortality were identified and weighted, using Cox regression, to create a risk score: male sex, 2 points; age (75-79, 2 points; 80-84, 2 points; ≥85, 3 points); dependence in toileting, 1 point; dependence in dressing (partial dependence, 1 point; full dependence, 3 points); malignant neoplasm, 2 points; congestive heart failure, 3 points; chronic obstructive pulmonary disease, 1 point; and renal insufficiency, 3 points. In the development cohort, respective 1- and 3-year mortality rates were 6% and 21% in the lowest-risk group (0-3 points), 12% and 36% in the middle-risk group (4-5 points), and 21% and 54% in the highest-risk group (>5 points). In the validation cohort, respective 1- and 3-year mortality rates were 7% and 18% in the lowest-risk group, 11% and 36% in the middle-risk group, and 22% and 55% in the highest-risk group. The area under the receiver operating characteristic curve for the point score was 0.66 and 0.69 in the development and validation cohorts, respectively. CONCLUSION: A multidimensional prognostic index was developed and validated using age, sex, functional status, and comorbidities that effectively stratifies frail, community-living elderly people into groups at varying risk of mortality.

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KW - Aging

KW - Frailty

KW - Functional impairment

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