Prediction of adverse outcomes by blood glucose level after endovascular therapy for acute ischemic stroke

Sabareesh K. Natarajan, Paresh Dandona, Yuval Karmon, Albert J. Yoo, Junaid S. Kalia, Qing Hao, Daniel P. Hsu, L. Nelson Hopkins, David J. Fiorella, Bernard Bendok, Thanh N. Nguyen, Marilyn M. Rymer, Ashish Nanda, David S. Liebeskind, Osama O. Zaidat, Raul G. Nogueira, Adnan H. Sidd Iqui, Elad I. Levy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Object. The authors evaluated the prognostic significance of blood glucose level at admission (BGA) and change in blood glucose at 48 hours from the baseline value (CG48) in nondiabetic and diabetic patients before and after endovascular therapy for acute ischemic stroke (AIS). Methods. The BGA and CG48 data were analyzed in 614 patients with AIS who received endovascular therapy at 7 US centers between 2006 and 2009. Data reviewed included demographics, stroke risk factors, diabetic status, National Institutes of Health Stroke Scale (NIHSS) score at presentation, recanalization grade, intracranial hemorrhage (ICH) rate, and 90-day outcomes (mortality rate and modified Rankin Scale score of 3-6 [defined as poor outcome]). Variables with p values < 0.2 in univariate analysis were included in a binary logistic regression model for independent predictors of 90-day outcomes. Results. The mean patient age was 67.3 years, the median NIHSS score was 16, and 27% of patients had diabetes. In nondiabetic patients, BGA ≥ 116 mg/dl (≥ 6.4 mmol/L) and failure of glucose level to drop > 30 mg/dl (> 1.7 mmol/L) from the admission value were both significant predictors of 90-day poor outcome and death (p < 0.001). In patients with diabetes, BGA ≥ 116 mg/dl (≥ 6.4 mmol/L) was an independent predictor of poor outcome (p = 0.001). The CG48 was not a predictor of outcome in diabetic patients. A simplified 6-point scale including BGA, Thrombolysis in Myocardial Infarction (TIMI) Grade 2-3 Reperfusion, Age, presentation NIHSS score, CG48, and symptomatic ICH (BRANCH) corresponded with poor outcomes at 90 days; the area under the curve value was > 0.79. Conclusions. Failure of blood glucose values to decrease in the first 48 hours after AIS intervention correlated with poor 90-day outcomes in nondiabetic patients. The BRANCH scale shows promise as a simple prognostication tool after endovascular therapy for AIS, and it merits prospective validation.

Original languageEnglish (US)
Pages (from-to)1785-1799
Number of pages15
JournalJournal of Neurosurgery
Volume114
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Blood Glucose
Stroke
Therapeutics
Intracranial Hemorrhages
National Institutes of Health (U.S.)
Demography
Mortality

Keywords

  • Acute ischemic stroke
  • Admission blood glucose
  • Change in blood glucose at 48 hours
  • Endovascular therapy
  • Prognostic scale
  • Vascular disorder

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Natarajan, S. K., Dandona, P., Karmon, Y., Yoo, A. J., Kalia, J. S., Hao, Q., ... Levy, E. I. (2011). Prediction of adverse outcomes by blood glucose level after endovascular therapy for acute ischemic stroke. Journal of Neurosurgery, 114(6), 1785-1799. https://doi.org/10.3171/2011.1.JNS10884

Prediction of adverse outcomes by blood glucose level after endovascular therapy for acute ischemic stroke. / Natarajan, Sabareesh K.; Dandona, Paresh; Karmon, Yuval; Yoo, Albert J.; Kalia, Junaid S.; Hao, Qing; Hsu, Daniel P.; Hopkins, L. Nelson; Fiorella, David J.; Bendok, Bernard; Nguyen, Thanh N.; Rymer, Marilyn M.; Nanda, Ashish; Liebeskind, David S.; Zaidat, Osama O.; Nogueira, Raul G.; Sidd Iqui, Adnan H.; Levy, Elad I.

In: Journal of Neurosurgery, Vol. 114, No. 6, 06.2011, p. 1785-1799.

Research output: Contribution to journalArticle

Natarajan, SK, Dandona, P, Karmon, Y, Yoo, AJ, Kalia, JS, Hao, Q, Hsu, DP, Hopkins, LN, Fiorella, DJ, Bendok, B, Nguyen, TN, Rymer, MM, Nanda, A, Liebeskind, DS, Zaidat, OO, Nogueira, RG, Sidd Iqui, AH & Levy, EI 2011, 'Prediction of adverse outcomes by blood glucose level after endovascular therapy for acute ischemic stroke', Journal of Neurosurgery, vol. 114, no. 6, pp. 1785-1799. https://doi.org/10.3171/2011.1.JNS10884
Natarajan, Sabareesh K. ; Dandona, Paresh ; Karmon, Yuval ; Yoo, Albert J. ; Kalia, Junaid S. ; Hao, Qing ; Hsu, Daniel P. ; Hopkins, L. Nelson ; Fiorella, David J. ; Bendok, Bernard ; Nguyen, Thanh N. ; Rymer, Marilyn M. ; Nanda, Ashish ; Liebeskind, David S. ; Zaidat, Osama O. ; Nogueira, Raul G. ; Sidd Iqui, Adnan H. ; Levy, Elad I. / Prediction of adverse outcomes by blood glucose level after endovascular therapy for acute ischemic stroke. In: Journal of Neurosurgery. 2011 ; Vol. 114, No. 6. pp. 1785-1799.
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AU - Natarajan, Sabareesh K.

AU - Dandona, Paresh

AU - Karmon, Yuval

AU - Yoo, Albert J.

AU - Kalia, Junaid S.

AU - Hao, Qing

AU - Hsu, Daniel P.

AU - Hopkins, L. Nelson

AU - Fiorella, David J.

AU - Bendok, Bernard

AU - Nguyen, Thanh N.

AU - Rymer, Marilyn M.

AU - Nanda, Ashish

AU - Liebeskind, David S.

AU - Zaidat, Osama O.

AU - Nogueira, Raul G.

AU - Sidd Iqui, Adnan H.

AU - Levy, Elad I.

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N2 - Object. The authors evaluated the prognostic significance of blood glucose level at admission (BGA) and change in blood glucose at 48 hours from the baseline value (CG48) in nondiabetic and diabetic patients before and after endovascular therapy for acute ischemic stroke (AIS). Methods. The BGA and CG48 data were analyzed in 614 patients with AIS who received endovascular therapy at 7 US centers between 2006 and 2009. Data reviewed included demographics, stroke risk factors, diabetic status, National Institutes of Health Stroke Scale (NIHSS) score at presentation, recanalization grade, intracranial hemorrhage (ICH) rate, and 90-day outcomes (mortality rate and modified Rankin Scale score of 3-6 [defined as poor outcome]). Variables with p values < 0.2 in univariate analysis were included in a binary logistic regression model for independent predictors of 90-day outcomes. Results. The mean patient age was 67.3 years, the median NIHSS score was 16, and 27% of patients had diabetes. In nondiabetic patients, BGA ≥ 116 mg/dl (≥ 6.4 mmol/L) and failure of glucose level to drop > 30 mg/dl (> 1.7 mmol/L) from the admission value were both significant predictors of 90-day poor outcome and death (p < 0.001). In patients with diabetes, BGA ≥ 116 mg/dl (≥ 6.4 mmol/L) was an independent predictor of poor outcome (p = 0.001). The CG48 was not a predictor of outcome in diabetic patients. A simplified 6-point scale including BGA, Thrombolysis in Myocardial Infarction (TIMI) Grade 2-3 Reperfusion, Age, presentation NIHSS score, CG48, and symptomatic ICH (BRANCH) corresponded with poor outcomes at 90 days; the area under the curve value was > 0.79. Conclusions. Failure of blood glucose values to decrease in the first 48 hours after AIS intervention correlated with poor 90-day outcomes in nondiabetic patients. The BRANCH scale shows promise as a simple prognostication tool after endovascular therapy for AIS, and it merits prospective validation.

AB - Object. The authors evaluated the prognostic significance of blood glucose level at admission (BGA) and change in blood glucose at 48 hours from the baseline value (CG48) in nondiabetic and diabetic patients before and after endovascular therapy for acute ischemic stroke (AIS). Methods. The BGA and CG48 data were analyzed in 614 patients with AIS who received endovascular therapy at 7 US centers between 2006 and 2009. Data reviewed included demographics, stroke risk factors, diabetic status, National Institutes of Health Stroke Scale (NIHSS) score at presentation, recanalization grade, intracranial hemorrhage (ICH) rate, and 90-day outcomes (mortality rate and modified Rankin Scale score of 3-6 [defined as poor outcome]). Variables with p values < 0.2 in univariate analysis were included in a binary logistic regression model for independent predictors of 90-day outcomes. Results. The mean patient age was 67.3 years, the median NIHSS score was 16, and 27% of patients had diabetes. In nondiabetic patients, BGA ≥ 116 mg/dl (≥ 6.4 mmol/L) and failure of glucose level to drop > 30 mg/dl (> 1.7 mmol/L) from the admission value were both significant predictors of 90-day poor outcome and death (p < 0.001). In patients with diabetes, BGA ≥ 116 mg/dl (≥ 6.4 mmol/L) was an independent predictor of poor outcome (p = 0.001). The CG48 was not a predictor of outcome in diabetic patients. A simplified 6-point scale including BGA, Thrombolysis in Myocardial Infarction (TIMI) Grade 2-3 Reperfusion, Age, presentation NIHSS score, CG48, and symptomatic ICH (BRANCH) corresponded with poor outcomes at 90 days; the area under the curve value was > 0.79. Conclusions. Failure of blood glucose values to decrease in the first 48 hours after AIS intervention correlated with poor 90-day outcomes in nondiabetic patients. The BRANCH scale shows promise as a simple prognostication tool after endovascular therapy for AIS, and it merits prospective validation.

KW - Acute ischemic stroke

KW - Admission blood glucose

KW - Change in blood glucose at 48 hours

KW - Endovascular therapy

KW - Prognostic scale

KW - Vascular disorder

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