TY - JOUR
T1 - Predicting Cognitive Impairment in Epilepsy
T2 - Findings from the Bozeman Epilepsy Consortium
AU - Strauss, Esther
AU - Loring, David
AU - Chelune, Gordon
AU - Hunter, Michael
AU - Hermann, Bruce
AU - Kenneth, K.
AU - Westerveld, Michael
AU - Trenerry, Max
AU - Barr, William
N1 - Funding Information:
The unique contribution of other variables is less certain. Seizure duration may also be associated with intellectual attainment, with longer seizure duration associated with poorer intellectual ability (Delaney, Rosen, Mattson, & Novelly 1980; Dikmen, 1980; Dikmen & Mathews, 1977; Singhi, Bansal, & Singhi, 1992; Tartar, 1972). The predictive power of seizure duration, however, appears weaker than age at seizure onset. Dodrill and Mathews (1992) found that the correlation between mental ability (FSIQ) and duration of disorder, although reliable, is smaller in magnitude (r = -. 13) than the relation between cognition and age at seizure onset (r = * This work was supported in part by grants from NSERC and The March of Dimes to E. Strauss. We thank Dr. Lou Costa for his helpful comments. The order of the second through to the eighth author was determined randomly. Drs. William Barr, Gordon Chelune, Bruce Hermann, David Loring, Ken Perrine, Esther Strauss, Max Trenerry, and Michael Westerveldt are all members of the Bozeman Epilepsy Consortium. Author's address for reprints: Esther Strauss Ph.D., Department of Psychology, University of Victoria, P.O.Box 3050, Victoria, British Columbia, Canada V8W 3P5. Accepted for publication: May 30, 1995.
PY - 1995/12/1
Y1 - 1995/12/1
N2 - We examined the contribution of age of seizure onset, seizure duration, seizure laterality, seizure location, gender, handedness, and cerebral speech representation to cognitive attainment in 1,141 patients with medically refractory seizures. The combined influence of the predictor variables was modest. Age of seizure onset was the best single indicator of Full Scale IQ (partial r -. 23) and General Memory (partial r =. 20). Laterality and location of dysfunction, and cerebral speech dominance were also relevant and independent indicators of aspects of cognition. Except for age of onset of seizures (early onset was associated with poorer cognitive attainment), however, the magnitude of the effects was limited.
AB - We examined the contribution of age of seizure onset, seizure duration, seizure laterality, seizure location, gender, handedness, and cerebral speech representation to cognitive attainment in 1,141 patients with medically refractory seizures. The combined influence of the predictor variables was modest. Age of seizure onset was the best single indicator of Full Scale IQ (partial r -. 23) and General Memory (partial r =. 20). Laterality and location of dysfunction, and cerebral speech dominance were also relevant and independent indicators of aspects of cognition. Except for age of onset of seizures (early onset was associated with poorer cognitive attainment), however, the magnitude of the effects was limited.
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U2 - 10.1080/01688639508402439
DO - 10.1080/01688639508402439
M3 - Article
C2 - 8847396
AN - SCOPUS:0029565472
SN - 1380-3395
VL - 17
SP - 909
EP - 917
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 6
ER -