Precocious puberty in a 7-year-old boy

A novel case

Christian A. Hettinger, John C. Cheville, Aida N. Lteif, Nathan A. Bradley, Stephen A. Kramer

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A 7-year-old boy was referred for evaluation of precocious puberty, evidenced by penile enlargement and pubic hair formation. His testicular size was prepubertal bilaterally. A comprehensive hormonal evaluation showed an elevated serum testosterone value (4.0 nmol/L) and a prepubertal gonadotropin value. A 0.9-cm heterogenous left testicular mass was detected on scrotal ultrasonography. Inguinal exploration was performed with ultrasound-guided open testicular biopsy and orchiectomy. Pathologic evaluation of the orchiectomy specimen showed the unclassified type of a mixed germ cell sex cord stromal tumor (MGCSCST), composed of neoplastic Sertoli cells and seminoma-like germ cells. Isolated previous reports of unclassified MGCSCSTs of the testis are now thought to be reports of sex cord stromal tumors with entrapped non-neoplastic germ cells. In our patient, the germ cells appeared to be neoplastic with aberrant expression of c-kit and placental alkaline phosphatase, a high proliferative rate, and DNA aneuploidy. Postoperatively, the patient's serum testosterone concentrations returned to prepubertal values (<0.2 nmol/L) and puberty was halted. This case represents a novel cause of precocious puberty.

Original languageEnglish (US)
Pages (from-to)412-414
Number of pages3
JournalJournal of Pediatric Urology
Volume5
Issue number5
DOIs
StatePublished - Oct 2009

Fingerprint

Precocious Puberty
Sex Cord-Gonadal Stromal Tumors
Germ Cells
Orchiectomy
Testosterone
Seminoma
Groin
Sertoli Cells
Germ Cell and Embryonal Neoplasms
Aneuploidy
Puberty
Serum
Gonadotropins
Hair
Testis
Ultrasonography
Biopsy
DNA

Keywords

  • Germinoma
  • Puberty
  • Sertoli cell tumor
  • Testicular neoplasms

ASJC Scopus subject areas

  • Urology
  • Pediatrics, Perinatology, and Child Health

Cite this

Hettinger, C. A., Cheville, J. C., Lteif, A. N., Bradley, N. A., & Kramer, S. A. (2009). Precocious puberty in a 7-year-old boy: A novel case. Journal of Pediatric Urology, 5(5), 412-414. https://doi.org/10.1016/j.jpurol.2009.05.004

Precocious puberty in a 7-year-old boy : A novel case. / Hettinger, Christian A.; Cheville, John C.; Lteif, Aida N.; Bradley, Nathan A.; Kramer, Stephen A.

In: Journal of Pediatric Urology, Vol. 5, No. 5, 10.2009, p. 412-414.

Research output: Contribution to journalArticle

Hettinger, CA, Cheville, JC, Lteif, AN, Bradley, NA & Kramer, SA 2009, 'Precocious puberty in a 7-year-old boy: A novel case', Journal of Pediatric Urology, vol. 5, no. 5, pp. 412-414. https://doi.org/10.1016/j.jpurol.2009.05.004
Hettinger CA, Cheville JC, Lteif AN, Bradley NA, Kramer SA. Precocious puberty in a 7-year-old boy: A novel case. Journal of Pediatric Urology. 2009 Oct;5(5):412-414. https://doi.org/10.1016/j.jpurol.2009.05.004
Hettinger, Christian A. ; Cheville, John C. ; Lteif, Aida N. ; Bradley, Nathan A. ; Kramer, Stephen A. / Precocious puberty in a 7-year-old boy : A novel case. In: Journal of Pediatric Urology. 2009 ; Vol. 5, No. 5. pp. 412-414.
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