TY - JOUR
T1 - Practice effects predict cognitive outcome in amnestic mild cognitive impairment
AU - Duff, Kevin
AU - Lyketsos, Constantine G.
AU - Beglinger, Leigh J.
AU - Chelune, Gordon
AU - Moser, David J.
AU - Arndt, Stephan
AU - Schultz, Susan K.
AU - Paulsen, Jane S.
AU - Petersen, Ronald C.
AU - McCaffrey, Robert J.
N1 - Funding Information:
The project described was supported by research grants from the National Institutes on Aging: K23 AG028417–01A2 (KD) and P50AG005 (CGL, Hopkins Alzheimer's Disease Research Center). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Aging or the National Institutes of Health.
PY - 2011/11
Y1 - 2011/11
N2 - OBJECTIVE:: Practice effects on cognitive tests have been shown to further characterize patients with amnestic mild cognitive impairment (aMCI) and may provide predictive information about cognitive change across time. We tested the hypothesis that a loss of practice effects would portend a worse prognosis in aMCI. DESIGN:: Longitudinal, observational design following participants across 1 year. SETTING:: Community-based cohort. PARTICIPANTS:: Three groups of older adults: 1) cognitively intact (n = 57), 2) aMCI with large practice effects across 1 week (MCI + PE, n = 25), and 3) aMCI with minimal practice effects across 1 week (MCI - PE, n = 26). MEASUREMENTS:: Neuropsychological tests. RESULTS:: After controlling for age and baseline cognitive differences, the MCI - PE group performed significantly worse than the other groups after 1 year on measures of immediate memory, delayed memory, language, and overall cognition. CONCLUSIONS:: Although these results need to be replicated in larger samples, the loss of short-term practice effects portends a worse prognosis in patients with aMCI.
AB - OBJECTIVE:: Practice effects on cognitive tests have been shown to further characterize patients with amnestic mild cognitive impairment (aMCI) and may provide predictive information about cognitive change across time. We tested the hypothesis that a loss of practice effects would portend a worse prognosis in aMCI. DESIGN:: Longitudinal, observational design following participants across 1 year. SETTING:: Community-based cohort. PARTICIPANTS:: Three groups of older adults: 1) cognitively intact (n = 57), 2) aMCI with large practice effects across 1 week (MCI + PE, n = 25), and 3) aMCI with minimal practice effects across 1 week (MCI - PE, n = 26). MEASUREMENTS:: Neuropsychological tests. RESULTS:: After controlling for age and baseline cognitive differences, the MCI - PE group performed significantly worse than the other groups after 1 year on measures of immediate memory, delayed memory, language, and overall cognition. CONCLUSIONS:: Although these results need to be replicated in larger samples, the loss of short-term practice effects portends a worse prognosis in patients with aMCI.
KW - Dementia
KW - Mild cognitive impairment
KW - Practice effects
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U2 - 10.1097/JGP.0b013e318209dd3a
DO - 10.1097/JGP.0b013e318209dd3a
M3 - Article
C2 - 22024617
AN - SCOPUS:80055054846
VL - 19
SP - 932
EP - 939
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
SN - 1064-7481
IS - 11
ER -