Abstract
OBJECTIVE:: Practice effects on cognitive tests have been shown to further characterize patients with amnestic mild cognitive impairment (aMCI) and may provide predictive information about cognitive change across time. We tested the hypothesis that a loss of practice effects would portend a worse prognosis in aMCI. DESIGN:: Longitudinal, observational design following participants across 1 year. SETTING:: Community-based cohort. PARTICIPANTS:: Three groups of older adults: 1) cognitively intact (n = 57), 2) aMCI with large practice effects across 1 week (MCI + PE, n = 25), and 3) aMCI with minimal practice effects across 1 week (MCI - PE, n = 26). MEASUREMENTS:: Neuropsychological tests. RESULTS:: After controlling for age and baseline cognitive differences, the MCI - PE group performed significantly worse than the other groups after 1 year on measures of immediate memory, delayed memory, language, and overall cognition. CONCLUSIONS:: Although these results need to be replicated in larger samples, the loss of short-term practice effects portends a worse prognosis in patients with aMCI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 932-939 |
| Number of pages | 8 |
| Journal | American Journal of Geriatric Psychiatry |
| Volume | 19 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2011 |
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Keywords
- Dementia
- Mild cognitive impairment
- Practice effects
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
Cite this
Practice effects predict cognitive outcome in amnestic mild cognitive impairment. / Duff, Kevin; Lyketsos, Constantine G.; Beglinger, Leigh J.; Chelune, Gordon; Moser, David J.; Arndt, Stephan; Schultz, Susan K.; Paulsen, Jane S.; Petersen, Ronald Carl; McCaffrey, Robert J.
In: American Journal of Geriatric Psychiatry, Vol. 19, No. 11, 11.2011, p. 932-939.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Practice effects predict cognitive outcome in amnestic mild cognitive impairment
AU - Duff, Kevin
AU - Lyketsos, Constantine G.
AU - Beglinger, Leigh J.
AU - Chelune, Gordon
AU - Moser, David J.
AU - Arndt, Stephan
AU - Schultz, Susan K.
AU - Paulsen, Jane S.
AU - Petersen, Ronald Carl
AU - McCaffrey, Robert J.
PY - 2011/11
Y1 - 2011/11
N2 - OBJECTIVE:: Practice effects on cognitive tests have been shown to further characterize patients with amnestic mild cognitive impairment (aMCI) and may provide predictive information about cognitive change across time. We tested the hypothesis that a loss of practice effects would portend a worse prognosis in aMCI. DESIGN:: Longitudinal, observational design following participants across 1 year. SETTING:: Community-based cohort. PARTICIPANTS:: Three groups of older adults: 1) cognitively intact (n = 57), 2) aMCI with large practice effects across 1 week (MCI + PE, n = 25), and 3) aMCI with minimal practice effects across 1 week (MCI - PE, n = 26). MEASUREMENTS:: Neuropsychological tests. RESULTS:: After controlling for age and baseline cognitive differences, the MCI - PE group performed significantly worse than the other groups after 1 year on measures of immediate memory, delayed memory, language, and overall cognition. CONCLUSIONS:: Although these results need to be replicated in larger samples, the loss of short-term practice effects portends a worse prognosis in patients with aMCI.
AB - OBJECTIVE:: Practice effects on cognitive tests have been shown to further characterize patients with amnestic mild cognitive impairment (aMCI) and may provide predictive information about cognitive change across time. We tested the hypothesis that a loss of practice effects would portend a worse prognosis in aMCI. DESIGN:: Longitudinal, observational design following participants across 1 year. SETTING:: Community-based cohort. PARTICIPANTS:: Three groups of older adults: 1) cognitively intact (n = 57), 2) aMCI with large practice effects across 1 week (MCI + PE, n = 25), and 3) aMCI with minimal practice effects across 1 week (MCI - PE, n = 26). MEASUREMENTS:: Neuropsychological tests. RESULTS:: After controlling for age and baseline cognitive differences, the MCI - PE group performed significantly worse than the other groups after 1 year on measures of immediate memory, delayed memory, language, and overall cognition. CONCLUSIONS:: Although these results need to be replicated in larger samples, the loss of short-term practice effects portends a worse prognosis in patients with aMCI.
KW - Dementia
KW - Mild cognitive impairment
KW - Practice effects
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UR - http://www.scopus.com/inward/citedby.url?scp=80055054846&partnerID=8YFLogxK
U2 - 10.1097/JGP.0b013e318209dd3a
DO - 10.1097/JGP.0b013e318209dd3a
M3 - Article
C2 - 22024617
AN - SCOPUS:80055054846
VL - 19
SP - 932
EP - 939
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
SN - 1064-7481
IS - 11
ER -