Postpartum remodeling, lactation, and breast cancer risk: Summary of a national cancer institute-sponsored workshop

Jessica M. Faupel-Badger, Kathleen F. Arcaro, Jane J. Balkam, A. Heather Eliassen, Foteini Hassiotou, Carlito B. Lebrilla, Karin B. Michels, Julie R. Palmer, Pepper Schedin, Alison M. Stuebe, Christine J. Watson, Mark E. Sherman

Research output: Contribution to journalReview article

59 Citations (Scopus)

Abstract

The pregnancy-lactation cycle (PLC) is a period in which the breast is transformed from a less-developed, nonfunctional organ into a mature, milk-producing gland that has evolved to meet the nutritional, developmental, and immune protection needs of the newborn. Cessation of lactation initiates a process whereby the breast reverts to a resting state until the next pregnancy. Changes during this period permanently alter the morphology and molecular characteristics of the breast (molecular histology) and produce important, yet poorly understood, effects on breast cancer risk. To provide a state-of-the-science summary of this topic, the National Cancer Institute invited a multidisciplinary group of experts to participate in a workshop in Rockville, Maryland, on March 2, 2012. Topics discussed included: 1) the epidemiology of the PLC in relation to breast cancer risk, 2) breast milk as a biospecimen for molecular epidemiological and translational research, and 3) use of animal models to gain mechanistic insights into the effects of the PLC on breast carcinogenesis. This report summarizes conclusions of the workshop, proposes avenues for future research on the PLC and its relationship with breast cancer risk, and identifies opportunities to translate this knowledge to improve breast cancer outcomes.

Original languageEnglish (US)
Pages (from-to)166-174
Number of pages9
JournalJournal of the National Cancer Institute
Volume105
Issue number3
DOIs
StatePublished - Feb 6 2013

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National Cancer Institute (U.S.)
Lactation
Postpartum Period
Breast Neoplasms
Education
Breast
Pregnancy
Translational Medical Research
Human Milk
Histology
Carcinogenesis
Milk
Epidemiology
Animal Models

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

Postpartum remodeling, lactation, and breast cancer risk : Summary of a national cancer institute-sponsored workshop. / Faupel-Badger, Jessica M.; Arcaro, Kathleen F.; Balkam, Jane J.; Heather Eliassen, A.; Hassiotou, Foteini; Lebrilla, Carlito B.; Michels, Karin B.; Palmer, Julie R.; Schedin, Pepper; Stuebe, Alison M.; Watson, Christine J.; Sherman, Mark E.

In: Journal of the National Cancer Institute, Vol. 105, No. 3, 06.02.2013, p. 166-174.

Research output: Contribution to journalReview article

Faupel-Badger, JM, Arcaro, KF, Balkam, JJ, Heather Eliassen, A, Hassiotou, F, Lebrilla, CB, Michels, KB, Palmer, JR, Schedin, P, Stuebe, AM, Watson, CJ & Sherman, ME 2013, 'Postpartum remodeling, lactation, and breast cancer risk: Summary of a national cancer institute-sponsored workshop', Journal of the National Cancer Institute, vol. 105, no. 3, pp. 166-174. https://doi.org/10.1093/jnci/djs505
Faupel-Badger, Jessica M. ; Arcaro, Kathleen F. ; Balkam, Jane J. ; Heather Eliassen, A. ; Hassiotou, Foteini ; Lebrilla, Carlito B. ; Michels, Karin B. ; Palmer, Julie R. ; Schedin, Pepper ; Stuebe, Alison M. ; Watson, Christine J. ; Sherman, Mark E. / Postpartum remodeling, lactation, and breast cancer risk : Summary of a national cancer institute-sponsored workshop. In: Journal of the National Cancer Institute. 2013 ; Vol. 105, No. 3. pp. 166-174.
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