Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers

Danielle Compton, Fabienne Wavrant DeVriéze, Ronald C. Petersen, Eric Tangalos, Ling Li, John Hardy

Research output: Contribution to journalArticle

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Abstract

Apolipoprotein(a) (Apo(a)) is a glycoprotein that is linked by a disulfide bond to apolipoprotein B on low density lipoprotein particles to form lipoprotein(a) (Lp(a)). High plasma levels of Lp(a) are thought to contribute directly to the development of atherosclerosis. We tested a variant (T3888P) located in the Kringle-IV region of Apo(a) in a case-control series. Overall, there were no differences between case and controls. However, in the apoE2 positive subgroup, we noticed that the mutant allele is over-represented in the cases (P=0.005). We suggest that this polymorphism and others at the Apo(a) locus be further studied in relation to Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalNeuroscience Letters
Volume331
Issue number1
DOIs
StatePublished - Oct 4 2002

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Keywords

  • Alzheimer's disease
  • Apolipoprotein(a)
  • Apolipoprotein(a) locus
  • Cholesterol
  • Lipoprotein(a)
  • Polymorphisms

ASJC Scopus subject areas

  • Neuroscience(all)

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