TY - JOUR
T1 - Position statement on ethics, equipoise and research on charged particle radiation therapy
AU - Sheehan, Mark
AU - Timlin, Claire
AU - Peach, Ken
AU - Binik, Ariella
AU - Puthenparampil, Wilson
AU - Lodge, Mark
AU - Kehoe, Sean
AU - Brada, Michael
AU - Burnet, Neil
AU - Clarke, Steve
AU - Crellin, Adrian
AU - Dunn, Michael
AU - Fossati, Piero
AU - Harris, Steve
AU - Hocken, Michael
AU - Hope, Tony
AU - Ives, Jonathan
AU - Kamada, Tadashi
AU - London, Alex John
AU - Miller, Robert
AU - Parker, Michael
AU - Pijls-Johannesma, Madelon
AU - Savulescu, Julian
AU - Short, Susan
AU - Skene, Loane
AU - Tsujii, Hirohiko
AU - Tuan, Jeffrey
AU - Weijer, Charles
PY - 2014
Y1 - 2014
N2 - The use of charged-particle radiation therapy (CPRT) is an increasingly important development in the treatment of cancer. One of the most pressing controversies about the use of this technology is whether randomised controlled trials are required before this form of treatment can be considered to be the treatment of choice for a wide range of indications. Equipoise is the key ethical concept in determining which research studies are justied. However, there is a good deal of disagreement about how this concept is best understood and applied in the specic case of CPRT. This report is a position statement on these controversies that arises out of a workshop held at Wolfson College, Oxford in August 2011. The workshop brought together international leaders in the relevant elds (radiation oncology, medical physics, radiobiology, research ethics and methodology), including proponents on both sides of the debate, in order to make signicant progress on the ethical issues associated with CPRT research. This position statement provides an ethical platform for future research and should enable further work to be done in developing international coordinated programmes of research.
AB - The use of charged-particle radiation therapy (CPRT) is an increasingly important development in the treatment of cancer. One of the most pressing controversies about the use of this technology is whether randomised controlled trials are required before this form of treatment can be considered to be the treatment of choice for a wide range of indications. Equipoise is the key ethical concept in determining which research studies are justied. However, there is a good deal of disagreement about how this concept is best understood and applied in the specic case of CPRT. This report is a position statement on these controversies that arises out of a workshop held at Wolfson College, Oxford in August 2011. The workshop brought together international leaders in the relevant elds (radiation oncology, medical physics, radiobiology, research ethics and methodology), including proponents on both sides of the debate, in order to make signicant progress on the ethical issues associated with CPRT research. This position statement provides an ethical platform for future research and should enable further work to be done in developing international coordinated programmes of research.
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U2 - 10.1136/medethics-2012-101290
DO - 10.1136/medethics-2012-101290
M3 - Article
C2 - 24045770
AN - SCOPUS:84904747517
SN - 0306-6800
VL - 40
SP - 572
EP - 575
JO - Journal of Medical Ethics
JF - Journal of Medical Ethics
IS - 8
ER -