Porous silicon-based scaffolds for tissue engineering and other biomedical applications

Jeffery L. Coffer; Melanie A. Whitehead; Dattatri K. Nagesha; Priyabrata Mukherjee; Giridhar Akkaraju; Mihaela Totolici; Roghieh S. Saffie; Leigh T. Canham

doi:10.1002/pssa.200461134

Porous silicon-based scaffolds for tissue engineering and other biomedical applications

Jeffery L. Coffer, Melanie A. Whitehead, Dattatri K. Nagesha, Priyabrata Mukherjee, Giridhar Akkaraju, Mihaela Totolici, Roghieh S. Saffie, Leigh T. Canham

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

This work describes the formation of porous composite materials based on a combination of bioactive mesoporous silicon and bioerodible polymers such as poly-caprolactone (PCL). The fabrication of a range of composites prepared by both salt leaching and microemulsion techniques are discussed. Particular attention to the influence of Si content in the composite on in vitro calcification assays are assessed. For each system, cytotoxicity and cellular proliferation are explicitly evaluated through fibroblast cell culture assays.

Original language	English (US)
Pages (from-to)	1451-1455
Number of pages	5
Journal	Physica Status Solidi (A) Applications and Materials Science
Volume	202
Issue number	8
DOIs	https://doi.org/10.1002/pssa.200461134
State	Published - Jun 2005

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Surfaces and Interfaces
Surfaces, Coatings and Films
Materials Chemistry
Electrical and Electronic Engineering

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10.1002/pssa.200461134

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abstract = "This work describes the formation of porous composite materials based on a combination of bioactive mesoporous silicon and bioerodible polymers such as poly-caprolactone (PCL). The fabrication of a range of composites prepared by both salt leaching and microemulsion techniques are discussed. Particular attention to the influence of Si content in the composite on in vitro calcification assays are assessed. For each system, cytotoxicity and cellular proliferation are explicitly evaluated through fibroblast cell culture assays.",

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AU - Whitehead, Melanie A.

AU - Nagesha, Dattatri K.

AU - Mukherjee, Priyabrata

AU - Akkaraju, Giridhar

AU - Totolici, Mihaela

AU - Saffie, Roghieh S.

AU - Canham, Leigh T.

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AB - This work describes the formation of porous composite materials based on a combination of bioactive mesoporous silicon and bioerodible polymers such as poly-caprolactone (PCL). The fabrication of a range of composites prepared by both salt leaching and microemulsion techniques are discussed. Particular attention to the influence of Si content in the composite on in vitro calcification assays are assessed. For each system, cytotoxicity and cellular proliferation are explicitly evaluated through fibroblast cell culture assays.

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Porous silicon-based scaffolds for tissue engineering and other biomedical applications

Abstract

ASJC Scopus subject areas

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