Polymyositis And Dermatomyositis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Polymyositis (PM) and dermatomyositis (DM) are idiopathic inflammatory myopathies of autoimmune origin involving the skeletal muscles. Pulmonary involvement occurs and is a source of morbidity and mortality. The main forms of pulmonary involvement include interstitial lung disease, respiratory muscle weakness, and aspiration pneumonia. Non-specific interstitial pneumonia, organizing pneumonia, usual interstitial pneumonia, diffuse alveolar damage, and lymphocytic interstitial pneumonia are the main histologic patterns found. Anti-Jo-1 antibody (anti-histidyl-tRNA synthetase) is commonly found in patients with PM/DM-associated interstitial lung disease. Progressive interstitial lung disease and respiratory muscle weakness can both cause respiratory failure. Aspiration pneumonia is related to weakness of the pharyngeal and upper esophageal muscles. Uncommon pulmonary manifestations include pleural effusion and pleuritis, pulmonary hypertension, and vasculitis. Corticosteroid therapy is the first line treatment and is generally effective in controlling both the myositis and the pulmonary involvement. However, in some patients PM/DM deteriorates despite corticosteroids and immunosuppressive therapy. Better understanding of the pathogenetic mechanisms in PM/DM will lead to more specific, target-directed therapy.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Respiratory Medicine, Four-Volume Set
PublisherElsevier Inc.
Pages479-485
Number of pages7
ISBN (Print)9780123708793
DOIs
StatePublished - Jan 1 2006

Fingerprint

Dermatomyositis
Interstitial Lung Diseases
Pulmonary diseases
Muscle
Aspiration Pneumonia
Lung
Respiratory Muscles
Myositis
Muscle Weakness
Histidine-tRNA Ligase
Adrenal Cortex Hormones
Respiratory Aspiration
Immunosuppressive Agents
Idiopathic Pulmonary Fibrosis
Pleurisy
Pleural Effusion
Therapeutics
Vasculitis
Pulmonary Hypertension
Respiratory Insufficiency

Keywords

  • Aspiration
  • Dermatomyositis
  • Interstitial lung disease
  • Interstitial pneumonia
  • Myopathy
  • Polymyositis
  • Respiratory muscle weakness

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ryu, J. H. (2006). Polymyositis And Dermatomyositis. In Encyclopedia of Respiratory Medicine, Four-Volume Set (pp. 479-485). Elsevier Inc.. https://doi.org/10.1016/B0-12-370879-6/00319-7

Polymyositis And Dermatomyositis. / Ryu, J. H.

Encyclopedia of Respiratory Medicine, Four-Volume Set. Elsevier Inc., 2006. p. 479-485.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ryu, JH 2006, Polymyositis And Dermatomyositis. in Encyclopedia of Respiratory Medicine, Four-Volume Set. Elsevier Inc., pp. 479-485. https://doi.org/10.1016/B0-12-370879-6/00319-7
Ryu JH. Polymyositis And Dermatomyositis. In Encyclopedia of Respiratory Medicine, Four-Volume Set. Elsevier Inc. 2006. p. 479-485 https://doi.org/10.1016/B0-12-370879-6/00319-7
Ryu, J. H. / Polymyositis And Dermatomyositis. Encyclopedia of Respiratory Medicine, Four-Volume Set. Elsevier Inc., 2006. pp. 479-485
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