Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior

Christopher J. Ward; Madhulika Sharma

doi:10.1016/j.cub.2015.09.061

Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior

Christopher J. Ward, Madhulika Sharma

Nephrology and Hypertension

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Male worm mating requires lov-1 and pkd-2 (homologs of the human polycystic kidney disease genes, PKD1 and PKD2), which are expressed in male-specific neurons. Transcriptomic analysis of these neurons now catalogs molecules involved in signaling and ectosome biogenesis, with implications for human PKD.

Original language	English (US)
Pages (from-to)	R1168-R1170
Journal	Current Biology
Volume	25
Issue number	24
DOIs	https://doi.org/10.1016/j.cub.2015.09.061
State	Published - Dec 21 2015

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1016/j.cub.2015.09.061

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title = "Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior",

abstract = "Male worm mating requires lov-1 and pkd-2 (homologs of the human polycystic kidney disease genes, PKD1 and PKD2), which are expressed in male-specific neurons. Transcriptomic analysis of these neurons now catalogs molecules involved in signaling and ectosome biogenesis, with implications for human PKD.",

author = "Ward, {Christopher J.} and Madhulika Sharma",

year = "2015",

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T2 - Lessons Learned from Caenorhabditis elegans Mating Behavior

AU - Ward, Christopher J.

AU - Sharma, Madhulika

PY - 2015/12/21

Y1 - 2015/12/21

N2 - Male worm mating requires lov-1 and pkd-2 (homologs of the human polycystic kidney disease genes, PKD1 and PKD2), which are expressed in male-specific neurons. Transcriptomic analysis of these neurons now catalogs molecules involved in signaling and ectosome biogenesis, with implications for human PKD.

AB - Male worm mating requires lov-1 and pkd-2 (homologs of the human polycystic kidney disease genes, PKD1 and PKD2), which are expressed in male-specific neurons. Transcriptomic analysis of these neurons now catalogs molecules involved in signaling and ectosome biogenesis, with implications for human PKD.

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DO - 10.1016/j.cub.2015.09.061

M3 - Short survey

AN - SCOPUS:84955507724

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SP - R1168-R1170

JO - Current Biology

JF - Current Biology

IS - 24

ER -

Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior

Abstract

ASJC Scopus subject areas

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