Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior

Christopher J. Ward, Madhulika Sharma

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

Male worm mating requires lov-1 and pkd-2 (homologs of the human polycystic kidney disease genes, PKD1 and PKD2), which are expressed in male-specific neurons. Transcriptomic analysis of these neurons now catalogs molecules involved in signaling and ectosome biogenesis, with implications for human PKD.

Original languageEnglish (US)
Pages (from-to)R1168-R1170
JournalCurrent Biology
Volume25
Issue number24
DOIs
StatePublished - Dec 21 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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