Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma

Curt T. DellaValle, Nicole C. Deziel, Rena R. Jones, Joanne S. Colt, Anneclaire J. De Roos, James R Cerhan, Wendy Cozen, Richard K. Severson, Abigail R. Flory, Lindsay M. Morton, Mary H. Ward

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Purpose: To investigate the risk of non-Hodgkin lymphoma (NHL) associated with residential carpet dust measurements of polycyclic aromatic hydrocarbons (PAHs). Methods: We evaluated the relationship between residential carpet dust PAH concentrations (benz(a)anthracene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, chrysene, dibenz(a,h)anthracene, and indeno(1,2,3-c,d)pyrene, and their sum) and risk of NHL (676 cases, 511 controls) in the National Cancer Institute Surveillance Epidemiology and End Results multicenter case–control study. As a secondary aim, we investigated determinants of dust PAH concentrations. We computed odds ratios (OR) and 95 % confidence interval (CI) for associations between NHL and concentrations of individual and summed PAHs using unconditional logistic regression, adjusting for age, gender, and study center. Determinants of natural log-transformed PAHs were investigated using multivariate least-squares regression. Results: We observed some elevated risks for NHL overall and B cell lymphoma subtypes in association with quartiles or tertiles of PAH concentrations, but without a monotonic trend, and there was no association comparing the highest quartile or tertile to the lowest. In contrast, risk of T cell lymphoma was significantly increased among participants with the highest tertile of summed PAHs (OR = 3.04; 95 % CI, 1.09–8.47) and benzo(k)fluoranthene (OR = 3.20; 95 % CI, 1.13–9.11) compared with the lowest tertile. Predictors of PAH dust concentrations in homes included ambient air PAH concentrations and the proportion of developed land within 2 km of a residence. Older age, more years of education, and white race were also predictive of higher levels in homes. Conclusion: Our results suggest a potential link between PAH exposure and risk of T cell lymphoma and demonstrate the importance of analyzing risk by NHL histologic type.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalCancer Causes and Control
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Case–control study
  • Dust
  • Non-Hodgkin lymphoma
  • Polycyclic aromatic hydrocarbons
  • T cell lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    DellaValle, C. T., Deziel, N. C., Jones, R. R., Colt, J. S., De Roos, A. J., Cerhan, J. R., Cozen, W., Severson, R. K., Flory, A. R., Morton, L. M., & Ward, M. H. (2016). Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma. Cancer Causes and Control, 27(1), 1-13. https://doi.org/10.1007/s10552-015-0660-y