PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2)

Esmaiel Jabbari, Anthony V. Florschutz, Lichun Lu, Nathan Liu, Larry G. Pedersen, D. H R Kempen, Bradford L. Currier, Michael J Yaszemski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of poly(DL-lactic-co-glycolic acid) (PLGA) microspheres embedded in a porous biodegradable poly(propylene fumarate) (PPF) scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2) was investigated. PLGA with a 50/50 or 75/25 lactide to glycolide ratio and weight average molecular weight of 25 or 60 Kg/mol was used for microsphere preparation. It was observed that the kinetics of release depended on the fraction of PLGA microspheres in the scaffold. The results show that embedding the microspheres in a porous PPF scaffold significantly reduces the burst release of rhBMP-2 and released amount can be controlled by the microsphere loading.

Original languageEnglish (US)
Title of host publicationAIChE Annual Meeting, Conference Proceedings
Pages1133-1136
Number of pages4
StatePublished - 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Other

Other2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

Fingerprint

Microspheres
Scaffolds
Bone
Proteins
Acids
Scaffolds (biology)
Propylene
Polypropylenes
Molecular weight
Milk
Kinetics

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Jabbari, E., Florschutz, A. V., Lu, L., Liu, N., Pedersen, L. G., Kempen, D. H. R., ... Yaszemski, M. J. (2004). PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2). In AIChE Annual Meeting, Conference Proceedings (pp. 1133-1136)

PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2). / Jabbari, Esmaiel; Florschutz, Anthony V.; Lu, Lichun; Liu, Nathan; Pedersen, Larry G.; Kempen, D. H R; Currier, Bradford L.; Yaszemski, Michael J.

AIChE Annual Meeting, Conference Proceedings. 2004. p. 1133-1136.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jabbari, E, Florschutz, AV, Lu, L, Liu, N, Pedersen, LG, Kempen, DHR, Currier, BL & Yaszemski, MJ 2004, PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2). in AIChE Annual Meeting, Conference Proceedings. pp. 1133-1136, 2004 AIChE Annual Meeting, Austin, TX, United States, 11/7/04.
Jabbari E, Florschutz AV, Lu L, Liu N, Pedersen LG, Kempen DHR et al. PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2). In AIChE Annual Meeting, Conference Proceedings. 2004. p. 1133-1136
Jabbari, Esmaiel ; Florschutz, Anthony V. ; Lu, Lichun ; Liu, Nathan ; Pedersen, Larry G. ; Kempen, D. H R ; Currier, Bradford L. ; Yaszemski, Michael J. / PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2). AIChE Annual Meeting, Conference Proceedings. 2004. pp. 1133-1136
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AU - Liu, Nathan

AU - Pedersen, Larry G.

AU - Kempen, D. H R

AU - Currier, Bradford L.

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