PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2)

Esmaiel Jabbari; Anthony V. Florschutz; Lichun Lu; Nathan Liu; Larry G. Pedersen; Diederik H.R. Kempen; Bradford L. Currier; Michael J. Yaszemski

PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2)

Esmaiel Jabbari, Anthony V. Florschutz, Lichun Lu, Nathan Liu, Larry G. Pedersen, Diederik H.R. Kempen, Bradford L. Currier, Michael J. Yaszemski

Orthopedic Surgery

Research output: Contribution to conference › Paper › peer-review

Abstract

The effect of poly(DL-lactic-co-glycolic acid) (PLGA) microspheres embedded in a porous biodegradable poly(propylene fumarate) (PPF) scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2) was investigated. PLGA with a 50/50 or 75/25 lactide to glycolide ratio and weight average molecular weight of 25 or 60 Kg/mol was used for microsphere preparation. It was observed that the kinetics of release depended on the fraction of PLGA microspheres in the scaffold. The results show that embedding the microspheres in a porous PPF scaffold significantly reduces the burst release of rhBMP-2 and released amount can be controlled by the microsphere loading.

Original language	English (US)
Pages	1133-1136
Number of pages	4
State	Published - 2004
Event	2004 AIChE Annual Meeting - Austin, TX, United States Duration: Nov 7 2004 → Nov 12 2004

Other

Other	2004 AIChE Annual Meeting
Country/Territory	United States
City	Austin, TX
Period	11/7/04 → 11/12/04

ASJC Scopus subject areas

General Engineering

Cite this

Jabbari, E., Florschutz, A. V., Lu, L., Liu, N., Pedersen, L. G., Kempen, D. H. R., Currier, B. L., & Yaszemski, M. J. (2004). PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2). 1133-1136. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.

PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2). / Jabbari, Esmaiel; Florschutz, Anthony V.; Lu, Lichun et al.
2004. 1133-1136 Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.

Research output: Contribution to conference › Paper › peer-review

Jabbari, E, Florschutz, AV, Lu, L, Liu, N, Pedersen, LG, Kempen, DHR, Currier, BL & Yaszemski, MJ 2004, 'PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2)', Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States, 11/7/04 - 11/12/04 pp. 1133-1136.

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abstract = "The effect of poly(DL-lactic-co-glycolic acid) (PLGA) microspheres embedded in a porous biodegradable poly(propylene fumarate) (PPF) scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2) was investigated. PLGA with a 50/50 or 75/25 lactide to glycolide ratio and weight average molecular weight of 25 or 60 Kg/mol was used for microsphere preparation. It was observed that the kinetics of release depended on the fraction of PLGA microspheres in the scaffold. The results show that embedding the microspheres in a porous PPF scaffold significantly reduces the burst release of rhBMP-2 and released amount can be controlled by the microsphere loading.",

author = "Esmaiel Jabbari and Florschutz, {Anthony V.} and Lichun Lu and Nathan Liu and Pedersen, {Larry G.} and Kempen, {Diederik H.R.} and Currier, {Bradford L.} and Yaszemski, {Michael J.}",

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AU - Jabbari, Esmaiel

AU - Florschutz, Anthony V.

AU - Lu, Lichun

AU - Liu, Nathan

AU - Pedersen, Larry G.

AU - Kempen, Diederik H.R.

AU - Currier, Bradford L.

AU - Yaszemski, Michael J.

PY - 2004

Y1 - 2004

N2 - The effect of poly(DL-lactic-co-glycolic acid) (PLGA) microspheres embedded in a porous biodegradable poly(propylene fumarate) (PPF) scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2) was investigated. PLGA with a 50/50 or 75/25 lactide to glycolide ratio and weight average molecular weight of 25 or 60 Kg/mol was used for microsphere preparation. It was observed that the kinetics of release depended on the fraction of PLGA microspheres in the scaffold. The results show that embedding the microspheres in a porous PPF scaffold significantly reduces the burst release of rhBMP-2 and released amount can be controlled by the microsphere loading.

AB - The effect of poly(DL-lactic-co-glycolic acid) (PLGA) microspheres embedded in a porous biodegradable poly(propylene fumarate) (PPF) scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2) was investigated. PLGA with a 50/50 or 75/25 lactide to glycolide ratio and weight average molecular weight of 25 or 60 Kg/mol was used for microsphere preparation. It was observed that the kinetics of release depended on the fraction of PLGA microspheres in the scaffold. The results show that embedding the microspheres in a porous PPF scaffold significantly reduces the burst release of rhBMP-2 and released amount can be controlled by the microsphere loading.

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T2 - 2004 AIChE Annual Meeting

Y2 - 7 November 2004 through 12 November 2004

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PLGA microspheres embedded in porous biodegradable scaffold as a delivery vehicle for sustained release of recombinant human bone morphogenetic protein-2 (rhBMP-2)

Abstract

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ASJC Scopus subject areas

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