Platelet glass bead retention predicts bleeding after cardiac surgery

Mark H. Ereth; Gregory A. Nuttall; Daniel G. Ericson; William P. Cooney IV; Brent R. Fisher; William C. Oliver; Hartzell V. Schaff; David N. Fass

doi:10.1053/jcan.2001.20274

Platelet glass bead retention predicts bleeding after cardiac surgery

Mark H. Ereth, Gregory A. Nuttall, Daniel G. Ericson, William P. Cooney IV, Brent R. Fisher, William C. Oliver, Hartzell V. Schaff, David N. Fass

Cardiovascular Surgery

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: To determine if the platelet glass bead retention assay can predict bleeding after cardiac surgery. Design: Prospective, observational study. Setting: Large, tertiary care, academic medical center. Participants: Forty-three adult patients scheduled to undergo elective cardiac surgery employing cardiopulmonary bypass (CPB). Measurements and Main Results: Whole blood samples were observed for platelet count, prothrombin time, and platelet (glass bead) retention assay. The platelet retention and prothrombin times were independent univariant and multivariant predictors of bleeding after CPB (r = 0.554, p = 0.0002 and r = 0.655, p = 0.00001). Conclusion: The platelet glass bead retention assay measures dynamic platelet function and is sensitive to the CPB-induced adhesion and aggregation defect and correlates with postoperative blood loss. Modification of this platelet function assay used with the prothrombin time may provide a simple and effective diagnostic approach to bleeding after CPB.

Original language	English (US)
Pages (from-to)	49-54
Number of pages	6
Journal	Journal of Cardiothoracic and Vascular Anesthesia
Volume	15
Issue number	1
DOIs	https://doi.org/10.1053/jcan.2001.20274
State	Published - Jan 1 2001

Keywords

Cardiac surgery
Cardiopulmonary bypass
Coagulation
Laboratory analysis
Monitoring
Platelet function
Platelet retention
Transfusion

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Anesthesiology and Pain Medicine

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10.1053/jcan.2001.20274

Cite this

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title = "Platelet glass bead retention predicts bleeding after cardiac surgery",

abstract = "Objective: To determine if the platelet glass bead retention assay can predict bleeding after cardiac surgery. Design: Prospective, observational study. Setting: Large, tertiary care, academic medical center. Participants: Forty-three adult patients scheduled to undergo elective cardiac surgery employing cardiopulmonary bypass (CPB). Measurements and Main Results: Whole blood samples were observed for platelet count, prothrombin time, and platelet (glass bead) retention assay. The platelet retention and prothrombin times were independent univariant and multivariant predictors of bleeding after CPB (r = 0.554, p = 0.0002 and r = 0.655, p = 0.00001). Conclusion: The platelet glass bead retention assay measures dynamic platelet function and is sensitive to the CPB-induced adhesion and aggregation defect and correlates with postoperative blood loss. Modification of this platelet function assay used with the prothrombin time may provide a simple and effective diagnostic approach to bleeding after CPB.",

keywords = "Cardiac surgery, Cardiopulmonary bypass, Coagulation, Laboratory analysis, Monitoring, Platelet function, Platelet retention, Transfusion",

author = "Ereth, {Mark H.} and Nuttall, {Gregory A.} and Ericson, {Daniel G.} and {Cooney IV}, {William P.} and Fisher, {Brent R.} and Oliver, {William C.} and Schaff, {Hartzell V.} and Fass, {David N.}",

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AU - Ereth, Mark H.

AU - Nuttall, Gregory A.

AU - Ericson, Daniel G.

AU - Cooney IV, William P.

AU - Fisher, Brent R.

AU - Oliver, William C.

AU - Schaff, Hartzell V.

AU - Fass, David N.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Objective: To determine if the platelet glass bead retention assay can predict bleeding after cardiac surgery. Design: Prospective, observational study. Setting: Large, tertiary care, academic medical center. Participants: Forty-three adult patients scheduled to undergo elective cardiac surgery employing cardiopulmonary bypass (CPB). Measurements and Main Results: Whole blood samples were observed for platelet count, prothrombin time, and platelet (glass bead) retention assay. The platelet retention and prothrombin times were independent univariant and multivariant predictors of bleeding after CPB (r = 0.554, p = 0.0002 and r = 0.655, p = 0.00001). Conclusion: The platelet glass bead retention assay measures dynamic platelet function and is sensitive to the CPB-induced adhesion and aggregation defect and correlates with postoperative blood loss. Modification of this platelet function assay used with the prothrombin time may provide a simple and effective diagnostic approach to bleeding after CPB.

AB - Objective: To determine if the platelet glass bead retention assay can predict bleeding after cardiac surgery. Design: Prospective, observational study. Setting: Large, tertiary care, academic medical center. Participants: Forty-three adult patients scheduled to undergo elective cardiac surgery employing cardiopulmonary bypass (CPB). Measurements and Main Results: Whole blood samples were observed for platelet count, prothrombin time, and platelet (glass bead) retention assay. The platelet retention and prothrombin times were independent univariant and multivariant predictors of bleeding after CPB (r = 0.554, p = 0.0002 and r = 0.655, p = 0.00001). Conclusion: The platelet glass bead retention assay measures dynamic platelet function and is sensitive to the CPB-induced adhesion and aggregation defect and correlates with postoperative blood loss. Modification of this platelet function assay used with the prothrombin time may provide a simple and effective diagnostic approach to bleeding after CPB.

KW - Cardiac surgery

KW - Cardiopulmonary bypass

KW - Coagulation

KW - Laboratory analysis

KW - Monitoring

KW - Platelet function

KW - Platelet retention

KW - Transfusion

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Platelet glass bead retention predicts bleeding after cardiac surgery

Abstract

Keywords

ASJC Scopus subject areas

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