Plasma levels of soluble glycoprotein 130 in acute myocardial infarction

Tomoko Ichiki, Michihisa Jougasaki, Manabu Setoguchi, Hiroto Shimokawahara, Hitoshi Nakashima, Tatsuru Matsuoka, Masahiro Sonoda, Kazuhiko Nakamura, Shinichi Minagoe, Chuwa Tei

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objectives: Soluble glycoprotein 130(sgpl30), a circulating form of receptor subunit for the interleukin (IL)-6 cytokine family, modulates the biological actions of its Jigands as an inhibitory regulator. The role of sgp 130 in cardiovascular diseases such as acute coronary syndrome remains unknown. Methods: Plasma levels of sgpl30 were examined by enzyme-linked immunosorbent assay in 33 patients with acute myocardial infarction (AMI; mean age 67 ± 2 years, 21 males and 12 females), who were admitted to our hospital within 24 hr of onset of AMI and survived for 4 weeks. Results: Plasma sgp 130 levels were significantly higher at admission (260.5 ± 7.3 ng/m/), and were significantly lower from day 2 to day 5 (202.4 ± 5.1 ng/m/at day 3) as compared with normal control subjects (n = 38, 227.1 ± 5.6 ng/m/). The lowest sgp130 levels inversely correlated with white blood cell count at admission (r = - 0.42, p < 0.05) and with peak C-reactive protein levels (r = - 0.43, p < 0.05). Additional in vitro study revealed that incubation of AMI plasma with exogenous IL-6 plus soluble IL-6 receptor resulted in a decrease in plasma sgp 130 levels, suggesting the possible reason for reduced plasma sgp 130 levels in AMI. Conclusions: The present study indicates that plasma sgp 130 levels were modulated during the time course of AMI and inversely associated with inflammation in AMI.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalJournal of Cardiology
Volume50
Issue number2
StatePublished - Dec 1 2007

Keywords

  • Blood cells
  • Cytokines
  • Myocardial infarction
  • Pathophysiology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Ichiki, T., Jougasaki, M., Setoguchi, M., Shimokawahara, H., Nakashima, H., Matsuoka, T., Sonoda, M., Nakamura, K., Minagoe, S., & Tei, C. (2007). Plasma levels of soluble glycoprotein 130 in acute myocardial infarction. Journal of Cardiology, 50(2), 101-109.