Plasma carotenoids and tocopherols in relation to prostate-specific antigen (PSA) levels among men with biochemical recurrence of prostate cancer

Samuel Antwi, Susan E. Steck, Hongmei Zhang, Lareissa Stumm, Jiajia Zhang, Thomas G. Hurley, James R. Hebert

Research output: Contribution to journalArticle

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Abstract

Background: Although men presenting with clinically localized prostate cancer (PrCA) often are treated with radical prostatectomy or radiation therapy with curative intent, about 25-40% develop biochemically recurrent PrCA within 5 years of treatment, which has no known cure. Studies suggest that carotenoid and tocopherol intake may be associated with PrCA risk and progression. We examined plasma carotenoid and tocopherol levels in relation to prostate-specific antigen (PSA) levels among men with PSA-defined biochemical recurrence of PrCA. Methods: Data analyzed were from a 6-month diet, physical activity and stress-reduction intervention trial conducted in South Carolina among biochemically recurrent PrCA patients (n= 39). Plasma carotenoids and tocopherol levels were measured using high-performance liquid chromatography (HPLC). Linear regression was used to estimate least-square means comparing PSA levels of men with high versus low carotenoid/tocopherol levels, adjusting for covariates. Results: After adjusting for baseline PSA level, plasma cis-lutein/zeaxanthin level at 3 months was related inversely to PSA level at 3 months (P= 0.0008), while α-tocopherol (P= 0.01), β-cryptoxanthin (P= 0.01), and all- trans-lycopene (P= 0.004) levels at 3 months were related inversely to PSA levels at 6-months. Percent increase in α-tocopherol and trans-β-carotene levels from baseline to month 3 were associated with lower PSA levels at 3 and 6 months. Percent increase in β-cryptoxanthin, cis-lutein/zeaxanthin and all- trans-lycopene were associated with lower PSA levels at 6 months only. Conclusions: Certain plasma carotenoids and tocopherols were related inversely to PSA levels at various timepoints, suggesting that greater intake of foods containing these micronutrients might be beneficial to men with PSA-defined PrCA recurrence.

Original languageEnglish (US)
Article number894
Pages (from-to)752-762
Number of pages11
JournalCancer Epidemiology
Volume39
Issue number5
DOIs
StatePublished - Oct 1 2015

Fingerprint

Tocopherols
Carotenoids
Prostate-Specific Antigen
Prostatic Neoplasms
Recurrence
Lutein
Micronutrients
Prostatectomy
Least-Squares Analysis
Linear Models
Radiotherapy
Eating
High Pressure Liquid Chromatography
Exercise
Diet

Keywords

  • Antioxidants
  • Biochemical recurrence
  • Carotenoids
  • Nutritional biomarkers
  • Prostate cancer
  • PSA
  • Tocopherols

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

Cite this

Plasma carotenoids and tocopherols in relation to prostate-specific antigen (PSA) levels among men with biochemical recurrence of prostate cancer. / Antwi, Samuel; Steck, Susan E.; Zhang, Hongmei; Stumm, Lareissa; Zhang, Jiajia; Hurley, Thomas G.; Hebert, James R.

In: Cancer Epidemiology, Vol. 39, No. 5, 894, 01.10.2015, p. 752-762.

Research output: Contribution to journalArticle

Antwi, Samuel ; Steck, Susan E. ; Zhang, Hongmei ; Stumm, Lareissa ; Zhang, Jiajia ; Hurley, Thomas G. ; Hebert, James R. / Plasma carotenoids and tocopherols in relation to prostate-specific antigen (PSA) levels among men with biochemical recurrence of prostate cancer. In: Cancer Epidemiology. 2015 ; Vol. 39, No. 5. pp. 752-762.
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T1 - Plasma carotenoids and tocopherols in relation to prostate-specific antigen (PSA) levels among men with biochemical recurrence of prostate cancer

AU - Antwi, Samuel

AU - Steck, Susan E.

AU - Zhang, Hongmei

AU - Stumm, Lareissa

AU - Zhang, Jiajia

AU - Hurley, Thomas G.

AU - Hebert, James R.

PY - 2015/10/1

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N2 - Background: Although men presenting with clinically localized prostate cancer (PrCA) often are treated with radical prostatectomy or radiation therapy with curative intent, about 25-40% develop biochemically recurrent PrCA within 5 years of treatment, which has no known cure. Studies suggest that carotenoid and tocopherol intake may be associated with PrCA risk and progression. We examined plasma carotenoid and tocopherol levels in relation to prostate-specific antigen (PSA) levels among men with PSA-defined biochemical recurrence of PrCA. Methods: Data analyzed were from a 6-month diet, physical activity and stress-reduction intervention trial conducted in South Carolina among biochemically recurrent PrCA patients (n= 39). Plasma carotenoids and tocopherol levels were measured using high-performance liquid chromatography (HPLC). Linear regression was used to estimate least-square means comparing PSA levels of men with high versus low carotenoid/tocopherol levels, adjusting for covariates. Results: After adjusting for baseline PSA level, plasma cis-lutein/zeaxanthin level at 3 months was related inversely to PSA level at 3 months (P= 0.0008), while α-tocopherol (P= 0.01), β-cryptoxanthin (P= 0.01), and all- trans-lycopene (P= 0.004) levels at 3 months were related inversely to PSA levels at 6-months. Percent increase in α-tocopherol and trans-β-carotene levels from baseline to month 3 were associated with lower PSA levels at 3 and 6 months. Percent increase in β-cryptoxanthin, cis-lutein/zeaxanthin and all- trans-lycopene were associated with lower PSA levels at 6 months only. Conclusions: Certain plasma carotenoids and tocopherols were related inversely to PSA levels at various timepoints, suggesting that greater intake of foods containing these micronutrients might be beneficial to men with PSA-defined PrCA recurrence.

AB - Background: Although men presenting with clinically localized prostate cancer (PrCA) often are treated with radical prostatectomy or radiation therapy with curative intent, about 25-40% develop biochemically recurrent PrCA within 5 years of treatment, which has no known cure. Studies suggest that carotenoid and tocopherol intake may be associated with PrCA risk and progression. We examined plasma carotenoid and tocopherol levels in relation to prostate-specific antigen (PSA) levels among men with PSA-defined biochemical recurrence of PrCA. Methods: Data analyzed were from a 6-month diet, physical activity and stress-reduction intervention trial conducted in South Carolina among biochemically recurrent PrCA patients (n= 39). Plasma carotenoids and tocopherol levels were measured using high-performance liquid chromatography (HPLC). Linear regression was used to estimate least-square means comparing PSA levels of men with high versus low carotenoid/tocopherol levels, adjusting for covariates. Results: After adjusting for baseline PSA level, plasma cis-lutein/zeaxanthin level at 3 months was related inversely to PSA level at 3 months (P= 0.0008), while α-tocopherol (P= 0.01), β-cryptoxanthin (P= 0.01), and all- trans-lycopene (P= 0.004) levels at 3 months were related inversely to PSA levels at 6-months. Percent increase in α-tocopherol and trans-β-carotene levels from baseline to month 3 were associated with lower PSA levels at 3 and 6 months. Percent increase in β-cryptoxanthin, cis-lutein/zeaxanthin and all- trans-lycopene were associated with lower PSA levels at 6 months only. Conclusions: Certain plasma carotenoids and tocopherols were related inversely to PSA levels at various timepoints, suggesting that greater intake of foods containing these micronutrients might be beneficial to men with PSA-defined PrCA recurrence.

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KW - Carotenoids

KW - Nutritional biomarkers

KW - Prostate cancer

KW - PSA

KW - Tocopherols

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