TY - JOUR
T1 - Plasma Biomarkers of Alzheimer's Disease in African Americans
AU - Deniz, Kaancan
AU - Ho, Charlotte C.G.
AU - Malphrus, Kimberly G.
AU - Reddy, Joseph S.
AU - Nguyen, Thuy
AU - Carnwath, Troy P.
AU - Crook, Julia E.
AU - Lucas, John A.
AU - Graff-Radford, Neill R.
AU - Carrasquillo, Minerva M.
AU - Ertekin-Taner, Nilüfer
AU - Belbin, Olivia
N1 - Publisher Copyright:
© 2021-The authors. Published by IOS Press.
PY - 2021
Y1 - 2021
N2 - Background/Objective: The aim of this study was to determine if plasma concentrations of 5 surrogate markers of Alzheimer's disease (AD) pathology and neuroinflammation are associated with disease status in African Americans. Methods: We evaluated 321 African Americans (159 AD, 162 controls) from the Florida Consortium for African-American Alzheimer's Disease Studies (FCA3DS). Five plasma proteins reflecting AD neuropathology or inflammation (Aβ42, tau, IL6, IL10, TNFα) were tested for associations with AD, age, sex, APOE and MAPT genotypes, and for pairwise correlations. Results: Plasma tau levels were higher in AD when adjusted for biological and technical covariates. APOE ϵ4 was associated with lower plasma Aβ42 and tau levels. Older age was associated with higher plasma Aβ42, tau, and TNFα. Females had lower IL10 levels. Inflammatory proteins had strong pairwise correlations amongst themselves and with Aβ42. Conclusion: We identified effects of demographic and genetic variants on five potential plasma biomarkers in African Americans. Plasma inflammatory biomarkers and Aβ42 may reflect correlated pathologies and elevated plasma tau may be a biomarker of AD in this population.
AB - Background/Objective: The aim of this study was to determine if plasma concentrations of 5 surrogate markers of Alzheimer's disease (AD) pathology and neuroinflammation are associated with disease status in African Americans. Methods: We evaluated 321 African Americans (159 AD, 162 controls) from the Florida Consortium for African-American Alzheimer's Disease Studies (FCA3DS). Five plasma proteins reflecting AD neuropathology or inflammation (Aβ42, tau, IL6, IL10, TNFα) were tested for associations with AD, age, sex, APOE and MAPT genotypes, and for pairwise correlations. Results: Plasma tau levels were higher in AD when adjusted for biological and technical covariates. APOE ϵ4 was associated with lower plasma Aβ42 and tau levels. Older age was associated with higher plasma Aβ42, tau, and TNFα. Females had lower IL10 levels. Inflammatory proteins had strong pairwise correlations amongst themselves and with Aβ42. Conclusion: We identified effects of demographic and genetic variants on five potential plasma biomarkers in African Americans. Plasma inflammatory biomarkers and Aβ42 may reflect correlated pathologies and elevated plasma tau may be a biomarker of AD in this population.
KW - African Americans
KW - Alzheimer's disease
KW - biomarkers
KW - minority health
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U2 - 10.3233/JAD-200828
DO - 10.3233/JAD-200828
M3 - Article
C2 - 33252078
AN - SCOPUS:85099031180
SN - 1387-2877
VL - 79
SP - 323
EP - 334
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -