Plasma Biomarkers of Alzheimer's Disease in African Americans

Kaancan Deniz, Charlotte C.G. Ho, Kimberly G. Malphrus, Joseph S. Reddy, Thuy Nguyen, Troy P. Carnwath, Julia E. Crook, John A. Lucas, Neill R. Graff-Radford, Minerva M. Carrasquillo, Nilüfer Ertekin-Taner, Olivia Belbin

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Objective: The aim of this study was to determine if plasma concentrations of 5 surrogate markers of Alzheimer's disease (AD) pathology and neuroinflammation are associated with disease status in African Americans. Methods: We evaluated 321 African Americans (159 AD, 162 controls) from the Florida Consortium for African-American Alzheimer's Disease Studies (FCA3DS). Five plasma proteins reflecting AD neuropathology or inflammation (Aβ42, tau, IL6, IL10, TNFα) were tested for associations with AD, age, sex, APOE and MAPT genotypes, and for pairwise correlations. Results: Plasma tau levels were higher in AD when adjusted for biological and technical covariates. APOE ϵ4 was associated with lower plasma Aβ42 and tau levels. Older age was associated with higher plasma Aβ42, tau, and TNFα. Females had lower IL10 levels. Inflammatory proteins had strong pairwise correlations amongst themselves and with Aβ42. Conclusion: We identified effects of demographic and genetic variants on five potential plasma biomarkers in African Americans. Plasma inflammatory biomarkers and Aβ42 may reflect correlated pathologies and elevated plasma tau may be a biomarker of AD in this population.

Original languageEnglish (US)
Pages (from-to)323-334
Number of pages12
JournalJournal of Alzheimer's Disease
Volume79
Issue number1
DOIs
StatePublished - 2021

Keywords

  • African Americans
  • Alzheimer's disease
  • biomarkers
  • minority health

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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