Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems

Yoshiki Matsuo, Takuro Takumi, Verghese Mathew, Woo Young Chung, Gregory W. Barsness, Charanjit Rihal, Rajiv Gulati, Eric T. McCue, David Holmes, Eric Eeckhout, Ryan J. Lennon, Lilach O Lerman, Amir Lerman

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Few studies have examined plaque characteristics among multiple arterial beds in vivo. The purpose of this study was to compare the plaque morphology and arterial remodeling between coronary and peripheral arteries using gray-scale and radiofrequency intravascular ultrasound (IVUS) at clinical presentation. Methods and results: IVUS imaging was performed in 68 patients with coronary and 93 with peripheral artery lesions (29 carotid, 50 renal, and 14 iliac arteries). Plaques were classified as fibroatheroma (VH-FA) (further subclassified as thin-capped [VH-TCFA] and thick-capped [VH-ThCFA]), fibrocalcific plaque (VH-FC) and pathological intimal thickening (VH-PIT). Plaque rupture (13% of coronary, 7% of carotid, 6% of renal, and 7% of iliac arteries; P = NS) and VH-TCFA (37% of coronary, 24% of carotid, 16% of renal, and 7% of iliac arteries; P = 0.02) were observed in all arteries. Compared with coronary arteries, VH-FA was less frequently observed in renal (P < 0.001) and iliac arteries (P < 0.006). Lesions with positive remodeling demonstrated more characteristics of VH-FA in coronary (84% vs. 25%, P < 0.001), carotid (72% vs. 20%, P = 0.001), and renal arteries (42% vs. 4%, P = 0.001) compared with those with intermediate/negative remodeling. There was positive relationship between remodeling index and percent necrotic area in all four arteries. Conclusions: Atherosclerotic plaque phenotypes were heterogeneous among four different arteries; renal and iliac arteries had more stable phenotypes compared with coronary artery. In contrast, the associations of remodeling pattern with plaque phenotype and composition were similar among the various arterial beds.

Original languageEnglish (US)
Pages (from-to)365-371
Number of pages7
JournalAtherosclerosis
Volume223
Issue number2
DOIs
StatePublished - Aug 2012

Fingerprint

Iliac Artery
Arteries
Kidney
Coronary Vessels
Renal Artery
Atherosclerotic Plaques
Phenotype
Tunica Intima
Rupture
Ultrasonography

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Intravascular ultrasound
  • Peripheral artery disease
  • Plaque morphology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems. / Matsuo, Yoshiki; Takumi, Takuro; Mathew, Verghese; Chung, Woo Young; Barsness, Gregory W.; Rihal, Charanjit; Gulati, Rajiv; McCue, Eric T.; Holmes, David; Eeckhout, Eric; Lennon, Ryan J.; Lerman, Lilach O; Lerman, Amir.

In: Atherosclerosis, Vol. 223, No. 2, 08.2012, p. 365-371.

Research output: Contribution to journalArticle

Matsuo, Y, Takumi, T, Mathew, V, Chung, WY, Barsness, GW, Rihal, C, Gulati, R, McCue, ET, Holmes, D, Eeckhout, E, Lennon, RJ, Lerman, LO & Lerman, A 2012, 'Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems', Atherosclerosis, vol. 223, no. 2, pp. 365-371. https://doi.org/10.1016/j.atherosclerosis.2012.05.023
Matsuo, Yoshiki ; Takumi, Takuro ; Mathew, Verghese ; Chung, Woo Young ; Barsness, Gregory W. ; Rihal, Charanjit ; Gulati, Rajiv ; McCue, Eric T. ; Holmes, David ; Eeckhout, Eric ; Lennon, Ryan J. ; Lerman, Lilach O ; Lerman, Amir. / Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems. In: Atherosclerosis. 2012 ; Vol. 223, No. 2. pp. 365-371.
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abstract = "Background: Few studies have examined plaque characteristics among multiple arterial beds in vivo. The purpose of this study was to compare the plaque morphology and arterial remodeling between coronary and peripheral arteries using gray-scale and radiofrequency intravascular ultrasound (IVUS) at clinical presentation. Methods and results: IVUS imaging was performed in 68 patients with coronary and 93 with peripheral artery lesions (29 carotid, 50 renal, and 14 iliac arteries). Plaques were classified as fibroatheroma (VH-FA) (further subclassified as thin-capped [VH-TCFA] and thick-capped [VH-ThCFA]), fibrocalcific plaque (VH-FC) and pathological intimal thickening (VH-PIT). Plaque rupture (13{\%} of coronary, 7{\%} of carotid, 6{\%} of renal, and 7{\%} of iliac arteries; P = NS) and VH-TCFA (37{\%} of coronary, 24{\%} of carotid, 16{\%} of renal, and 7{\%} of iliac arteries; P = 0.02) were observed in all arteries. Compared with coronary arteries, VH-FA was less frequently observed in renal (P < 0.001) and iliac arteries (P < 0.006). Lesions with positive remodeling demonstrated more characteristics of VH-FA in coronary (84{\%} vs. 25{\%}, P < 0.001), carotid (72{\%} vs. 20{\%}, P = 0.001), and renal arteries (42{\%} vs. 4{\%}, P = 0.001) compared with those with intermediate/negative remodeling. There was positive relationship between remodeling index and percent necrotic area in all four arteries. Conclusions: Atherosclerotic plaque phenotypes were heterogeneous among four different arteries; renal and iliac arteries had more stable phenotypes compared with coronary artery. In contrast, the associations of remodeling pattern with plaque phenotype and composition were similar among the various arterial beds.",
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T1 - Plaque characteristics and arterial remodeling in coronary and peripheral arterial systems

AU - Matsuo, Yoshiki

AU - Takumi, Takuro

AU - Mathew, Verghese

AU - Chung, Woo Young

AU - Barsness, Gregory W.

AU - Rihal, Charanjit

AU - Gulati, Rajiv

AU - McCue, Eric T.

AU - Holmes, David

AU - Eeckhout, Eric

AU - Lennon, Ryan J.

AU - Lerman, Lilach O

AU - Lerman, Amir

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N2 - Background: Few studies have examined plaque characteristics among multiple arterial beds in vivo. The purpose of this study was to compare the plaque morphology and arterial remodeling between coronary and peripheral arteries using gray-scale and radiofrequency intravascular ultrasound (IVUS) at clinical presentation. Methods and results: IVUS imaging was performed in 68 patients with coronary and 93 with peripheral artery lesions (29 carotid, 50 renal, and 14 iliac arteries). Plaques were classified as fibroatheroma (VH-FA) (further subclassified as thin-capped [VH-TCFA] and thick-capped [VH-ThCFA]), fibrocalcific plaque (VH-FC) and pathological intimal thickening (VH-PIT). Plaque rupture (13% of coronary, 7% of carotid, 6% of renal, and 7% of iliac arteries; P = NS) and VH-TCFA (37% of coronary, 24% of carotid, 16% of renal, and 7% of iliac arteries; P = 0.02) were observed in all arteries. Compared with coronary arteries, VH-FA was less frequently observed in renal (P < 0.001) and iliac arteries (P < 0.006). Lesions with positive remodeling demonstrated more characteristics of VH-FA in coronary (84% vs. 25%, P < 0.001), carotid (72% vs. 20%, P = 0.001), and renal arteries (42% vs. 4%, P = 0.001) compared with those with intermediate/negative remodeling. There was positive relationship between remodeling index and percent necrotic area in all four arteries. Conclusions: Atherosclerotic plaque phenotypes were heterogeneous among four different arteries; renal and iliac arteries had more stable phenotypes compared with coronary artery. In contrast, the associations of remodeling pattern with plaque phenotype and composition were similar among the various arterial beds.

AB - Background: Few studies have examined plaque characteristics among multiple arterial beds in vivo. The purpose of this study was to compare the plaque morphology and arterial remodeling between coronary and peripheral arteries using gray-scale and radiofrequency intravascular ultrasound (IVUS) at clinical presentation. Methods and results: IVUS imaging was performed in 68 patients with coronary and 93 with peripheral artery lesions (29 carotid, 50 renal, and 14 iliac arteries). Plaques were classified as fibroatheroma (VH-FA) (further subclassified as thin-capped [VH-TCFA] and thick-capped [VH-ThCFA]), fibrocalcific plaque (VH-FC) and pathological intimal thickening (VH-PIT). Plaque rupture (13% of coronary, 7% of carotid, 6% of renal, and 7% of iliac arteries; P = NS) and VH-TCFA (37% of coronary, 24% of carotid, 16% of renal, and 7% of iliac arteries; P = 0.02) were observed in all arteries. Compared with coronary arteries, VH-FA was less frequently observed in renal (P < 0.001) and iliac arteries (P < 0.006). Lesions with positive remodeling demonstrated more characteristics of VH-FA in coronary (84% vs. 25%, P < 0.001), carotid (72% vs. 20%, P = 0.001), and renal arteries (42% vs. 4%, P = 0.001) compared with those with intermediate/negative remodeling. There was positive relationship between remodeling index and percent necrotic area in all four arteries. Conclusions: Atherosclerotic plaque phenotypes were heterogeneous among four different arteries; renal and iliac arteries had more stable phenotypes compared with coronary artery. In contrast, the associations of remodeling pattern with plaque phenotype and composition were similar among the various arterial beds.

KW - Atherosclerosis

KW - Coronary artery disease

KW - Intravascular ultrasound

KW - Peripheral artery disease

KW - Plaque morphology

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