Planktonic and Biofilm Activity of Eravacycline against Staphylococci Isolated from Periprosthetic Joint Infections

Georg Zhuchenko, Suzannah Schmidt-Malan, Robin Patel

Research output: Contribution to journalArticlepeer-review

Abstract

MIC and minimum biofilm bactericidal concentration (MBBC) values of eravacycline against 185 staphylococci from periprosthetic joint infections were determined. Staphylococcus aureus had MICs of ≤0.25 μg/ml. MICs for methicillin-susceptible and -resistant Staphylococcus epidermidis were ≤1 and ≤2 μg/ml, respectively. S. aureus and S. epidermidis MBBC50 and MBBC90 values were 8 and 16 μg/ml for each, showing poor anti-staphylococcal biofilm activity using the method studied.

Original languageEnglish (US)
Article numbere01304
JournalAntimicrobial Agents and Chemotherapy
Volume64
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Biofilm
  • Biofilm susceptibility
  • Eravacycline
  • Periprosthetic joint infection
  • Staphylococci

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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