MIC and minimum biofilm bactericidal concentration (MBBC) values of eravacycline against 185 staphylococci from periprosthetic joint infections were determined. Staphylococcus aureus had MICs of ≤0.25 μg/ml. MICs for methicillin-susceptible and -resistant Staphylococcus epidermidis were ≤1 and ≤2 μg/ml, respectively. S. aureus and S. epidermidis MBBC50 and MBBC90 values were 8 and 16 μg/ml for each, showing poor anti-staphylococcal biofilm activity using the method studied.
- Biofilm susceptibility
- Periprosthetic joint infection
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases