Planktonic and Biofilm Activity of Eravacycline against Staphylococci Isolated from Periprosthetic Joint Infections

Georg Zhuchenko; Suzannah Schmidt-Malan; Robin Patel

doi:10.1128/AAC.01304-20

Planktonic and Biofilm Activity of Eravacycline against Staphylococci Isolated from Periprosthetic Joint Infections

Georg Zhuchenko, Suzannah Schmidt-Malan, Robin Patel

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

MIC and minimum biofilm bactericidal concentration (MBBC) values of eravacycline against 185 staphylococci from periprosthetic joint infections were determined. Staphylococcus aureus had MICs of ≤0.25 μg/ml. MICs for methicillin-susceptible and -resistant Staphylococcus epidermidis were ≤1 and ≤2 μg/ml, respectively. S. aureus and S. epidermidis MBBC₅₀ and MBBC₉₀ values were 8 and 16 μg/ml for each, showing poor anti-staphylococcal biofilm activity using the method studied.

Original language	English (US)
Article number	e01304
Journal	Antimicrobial Agents and Chemotherapy
Volume	64
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01304-20
State	Published - Dec 2020

Keywords

Biofilm
Biofilm susceptibility
Eravacycline
Periprosthetic joint infection
Staphylococci

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01304-20

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title = "Planktonic and Biofilm Activity of Eravacycline against Staphylococci Isolated from Periprosthetic Joint Infections",

abstract = "MIC and minimum biofilm bactericidal concentration (MBBC) values of eravacycline against 185 staphylococci from periprosthetic joint infections were determined. Staphylococcus aureus had MICs of ≤0.25 μg/ml. MICs for methicillin-susceptible and -resistant Staphylococcus epidermidis were ≤1 and ≤2 μg/ml, respectively. S. aureus and S. epidermidis MBBC50 and MBBC90 values were 8 and 16 μg/ml for each, showing poor anti-staphylococcal biofilm activity using the method studied.",

keywords = "Biofilm, Biofilm susceptibility, Eravacycline, Periprosthetic joint infection, Staphylococci",

author = "Georg Zhuchenko and Suzannah Schmidt-Malan and Robin Patel",

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doi = "10.1128/AAC.01304-20",

language = "English (US)",

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journal = "Antimicrobial Agents and Chemotherapy",

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T1 - Planktonic and Biofilm Activity of Eravacycline against Staphylococci Isolated from Periprosthetic Joint Infections

AU - Zhuchenko, Georg

AU - Schmidt-Malan, Suzannah

AU - Patel, Robin

PY - 2020/12

Y1 - 2020/12

N2 - MIC and minimum biofilm bactericidal concentration (MBBC) values of eravacycline against 185 staphylococci from periprosthetic joint infections were determined. Staphylococcus aureus had MICs of ≤0.25 μg/ml. MICs for methicillin-susceptible and -resistant Staphylococcus epidermidis were ≤1 and ≤2 μg/ml, respectively. S. aureus and S. epidermidis MBBC50 and MBBC90 values were 8 and 16 μg/ml for each, showing poor anti-staphylococcal biofilm activity using the method studied.

AB - MIC and minimum biofilm bactericidal concentration (MBBC) values of eravacycline against 185 staphylococci from periprosthetic joint infections were determined. Staphylococcus aureus had MICs of ≤0.25 μg/ml. MICs for methicillin-susceptible and -resistant Staphylococcus epidermidis were ≤1 and ≤2 μg/ml, respectively. S. aureus and S. epidermidis MBBC50 and MBBC90 values were 8 and 16 μg/ml for each, showing poor anti-staphylococcal biofilm activity using the method studied.

KW - Biofilm

KW - Biofilm susceptibility

KW - Eravacycline

KW - Periprosthetic joint infection

KW - Staphylococci

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DO - 10.1128/AAC.01304-20

M3 - Article

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AN - SCOPUS:85096357179

SN - 0066-4804

VL - 64

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 12

M1 - e01304

ER -

Planktonic and Biofilm Activity of Eravacycline against Staphylococci Isolated from Periprosthetic Joint Infections

Abstract

Keywords

ASJC Scopus subject areas

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