Pituitary and thyroid function in male cynomolgus monkeys

Robert Christian Smallridge, I. Mehlman, C. L. Pamplin, N. E. Whorton, R. C. Dimond, T. Doyle, L. Wartofsky

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

In four male cynomolgus monkeys, serum thyrosine was 6.2±0.9 μg/dl, and triiodothyronine was 207±12 ng/dl (mean ±SE). Kinetic studies using 131I-thyroxine and 125I-triiodothyronine showed that the disappearance of both hormones was non-linear and best fit a biexponential equation. The metabolic clearance rates and production rates for thyroxine were 21.5±0.6 ml/kg/day and 1.34±0.23 μg/kg/day, respectively, and T1/2(β)=29.6±2.0 hours. For triiodothyronine, the metabolic clearance rate was 156.6±12.0 ml/kg/day, the production rate was 0.33±0.04 μg/kg/day, and T1/2(β) was 13.3±1.3 hours. Basal serum thyrotropin levels in five euthyroid animals were 1.4±0.6 μU/ml and increased after thyrotropin-releasing hormone to 6.7±2.2 μU/ml. Serum prolactin was 5.8±0.7 ng/ml, and it increased to 26.6±4.5 ng/ml after thyrotropin-releasing hormone. Four animals received chronic dexamethasone therapy (1 mg twice daily for 5.5. months). While baseline and thyrotropin-releasing hormone stimulated thyrotropin values were lower (0.8±0.2 μU/ml and 3.2±0.5 μU/ml, respectively), these reductions were not significant.

Original languageEnglish (US)
Title of host publicationLaboratory Animal Science
Pages693-696
Number of pages4
Volume31
Edition6
StatePublished - 1981
Externally publishedYes

Fingerprint

Thyrotropin-Releasing Hormone
Macaca fascicularis
Triiodothyronine
Metabolic Clearance Rate
Thyroid Gland
Thyrotropin
Thyroxine
Serum
Prolactin
Dexamethasone
Hormones
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Smallridge, R. C., Mehlman, I., Pamplin, C. L., Whorton, N. E., Dimond, R. C., Doyle, T., & Wartofsky, L. (1981). Pituitary and thyroid function in male cynomolgus monkeys. In Laboratory Animal Science (6 ed., Vol. 31, pp. 693-696)

Pituitary and thyroid function in male cynomolgus monkeys. / Smallridge, Robert Christian; Mehlman, I.; Pamplin, C. L.; Whorton, N. E.; Dimond, R. C.; Doyle, T.; Wartofsky, L.

Laboratory Animal Science. Vol. 31 6. ed. 1981. p. 693-696.

Research output: Chapter in Book/Report/Conference proceedingChapter

Smallridge, RC, Mehlman, I, Pamplin, CL, Whorton, NE, Dimond, RC, Doyle, T & Wartofsky, L 1981, Pituitary and thyroid function in male cynomolgus monkeys. in Laboratory Animal Science. 6 edn, vol. 31, pp. 693-696.
Smallridge RC, Mehlman I, Pamplin CL, Whorton NE, Dimond RC, Doyle T et al. Pituitary and thyroid function in male cynomolgus monkeys. In Laboratory Animal Science. 6 ed. Vol. 31. 1981. p. 693-696
Smallridge, Robert Christian ; Mehlman, I. ; Pamplin, C. L. ; Whorton, N. E. ; Dimond, R. C. ; Doyle, T. ; Wartofsky, L. / Pituitary and thyroid function in male cynomolgus monkeys. Laboratory Animal Science. Vol. 31 6. ed. 1981. pp. 693-696
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