Phosphorus disorders: Hypophosphatemic rickets

Bart L. Clarke

doi:10.1007/978-3-030-03694-2

Phosphorus disorders: Hypophosphatemic rickets

Bart L. Clarke

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Phosphorus is a critical element for skeletal development and maturation, as well as bone mineralization, cell membrane structure, nucleotide formation, and intracellular signaling. Phosphorus forms complexes with oxygen in living tissues to form anionic phosphate. Phosphate homeostasis in humans is largely maintained by the balance between parathyroid hormone (PTH), 1,25-dihydroxyvitamin D, and fibroblast growth factor-23 (FGF-23). Serum phosphorus is influenced by these hormones, as well as by dietary intake, acid-based changes in the blood, renal function, skeletal metabolism, and intestinal absorption.

Original language	English (US)
Title of host publication	Metabolic Bone Diseases
Subtitle of host publication	A Case-Based Approach
Publisher	Springer International Publishing
Pages	83-98
Number of pages	16
ISBN (Electronic)	9783030036942
ISBN (Print)	9783030036935
DOIs	https://doi.org/10.1007/978-3-030-03694-2
State	Published - Jan 1 2019

Keywords

25-Dihydroxyvitamin D
Autosomal-dominant hypophosphatemic rickets
FGF-23 1
Hypophosphatemia
Osteomalacia
Rickets
Tumor-induced osteomalacia
X-linked hypophosphatemic rickets

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-030-03694-2

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abstract = "Phosphorus is a critical element for skeletal development and maturation, as well as bone mineralization, cell membrane structure, nucleotide formation, and intracellular signaling. Phosphorus forms complexes with oxygen in living tissues to form anionic phosphate. Phosphate homeostasis in humans is largely maintained by the balance between parathyroid hormone (PTH), 1,25-dihydroxyvitamin D, and fibroblast growth factor-23 (FGF-23). Serum phosphorus is influenced by these hormones, as well as by dietary intake, acid-based changes in the blood, renal function, skeletal metabolism, and intestinal absorption.",

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KW - Tumor-induced osteomalacia

KW - X-linked hypophosphatemic rickets

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Phosphorus disorders: Hypophosphatemic rickets

Abstract

Keywords

ASJC Scopus subject areas

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