"Phosphatonins" and the regulation of phosphorus homeostasis

Theresa J. Berndt, Susan Schiavi, Rajiv Kumar

Research output: Contribution to journalReview article

163 Scopus citations

Abstract

Phosphate ions are critical for normal bone mineralization, and phosphate plays a vital role in a number of other biological processes such as signal transduction, nucleotide metabolism, and enzyme regulation. The study of rare disorders associated with renal phosphate wasting has resulted in the discovery of a number of proteins [fibroblast growth factor 23 (FGF-23), secreted frizzled related protein 4 (sFRP-4), matrix extracellular phosphoglycoprotein, and FGF 7 (FGF-7)] that decrease renal sodium-dependent phosphate transport in vivo and in vitro. The "phosphatonins," FGF-23 and sFRP-4, also inhibit the synthesis of 1α,25-dihydroxyvitamin D, leading to decreased intestinal phosphate absorption and further reduction in phosphate retention by the organism. In this review, we discuss the biological properties of these proteins, alterations in their concentrations in various clinical, disorders, and their possible physiological role.

Original languageEnglish (US)
Pages (from-to)F1170-F1182
JournalAmerican Journal of Physiology - Renal Physiology
Volume289
Issue number6 58-6
DOIs
StatePublished - Dec 2005

Keywords

  • Fibroblast growth factor 23
  • Matrix extracellular phosphoglycoprotein
  • Phosphate
  • Secreted frizzled related protein 4
  • Vitamin D

ASJC Scopus subject areas

  • Physiology
  • Urology

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