Research output: Chapter in Book/Report/Conference proceedingChapter


Phosphorus plays an integral role in energy homeostasis, enzyme function, cell membrane integrity, and skeletal mineralization. Phosphorus balance is determined by intestinal absorption, renal reabsorption, and skeletal utilization and is regulated by vitamin D, parathyroid hormone, and other phosphate regulating factors referred to as phosphatonins. These phosphaturic peptides, fibroblast growth factor 23 (FGF23), secreted frizzled-related protein 4 (sFRP4), matrix extracellular phosphoglycoprotein, and fibroblast growth factor 7 play an important role in normal and abnormal phosphate homeostasis primarily by inhibiting sodium-phosphate cotransporter-mediated renal phosphate reabsorption. FGF23 and sFRP4 also inhibit production of 1α, 25-dihydroxyvitamin D3 thereby reducing intestinal phosphate absorption. Several hypophosphatemic disorders, including X-linked hypophosphatemic rickets (XLH) and tumor-induced osteomalacia, are caused by inappropriately high concentrations of phosphatonins, while inadequate FGF23 leads to hyperphosphatemia and tumoral calcinosis. The study of phosphatonins has greatly expanded out knowledge of phosphate homeostasis and led to novel treatment for XLH.

Original languageEnglish (US)
Title of host publicationMarcus and Feldman’s Osteoporosis
Number of pages19
ISBN (Electronic)9780128130735
StatePublished - Jan 1 2020


  • Fibroblast growth factor
  • Osteomalacia
  • Phosphorus
  • Rickets
  • Sodium-phosphate cotransporter
  • Vitamin D

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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