Phenotypic Variation of Colonic Motor Functions in Chronic Constipation

Karthik Ravi, Adil Eddie Bharucha, Michael Camilleri, Deborah Rhoten, Timothy Bakken, Alan R. Zinsmeister

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background & Aims: Colonic motor disturbances in chronic constipation (CC) are heterogeneous and incompletely understood; the relationship between colonic transit and motor activity is unclear. We sought to characterize the phenotypic variability in chronic constipation. Methods: Fasting and postprandial colonic tone and phasic activity and pressure-volume relationships were assessed by a barostat manometric assembly in 35 healthy women and 111 women with CC who had normal colon transit (NTC; n = 25), slow transit (STC; n = 19), and defecatory disorders with normal (DD-normal; n = 34) or slow transit (DD-slow; n = 33). Logistic regression models assessed whether motor parameters could discriminate among these groups. Among CC, phenotypes were characterized by principal components analysis of these measurements. Results: Compared with 10th percentile values in healthy subjects, fasting and/or postprandial colonic tone and/or compliance were reduced in 40% with NTC, 47% with STC, 53% with DD-normal, and 42% with DD-slow transit. Compared with healthy subjects, compliance was reduced (P ≤ .05) in isolated STC and DD but not in NTC. Four principal components accounted for 85% of the total variation among patients: factors 1 and 2 were predominantly weighted by fasting and postprandial colonic phasic activity and tone, respectively; factor 3 by postprandial high-amplitude propagated contractions; and factor 4 by postprandial tonic response. Conclusions: Fasting and/or postprandial colonic tone are reduced, reflecting motor dysfunctions, even in NTC. Colonic motor assessments allow chronic constipation to be characterized into phenotypes. Further studies are needed to evaluate the relationship among these phenotypes, enteric neuropathology, and response to treatment in CC.

Original languageEnglish (US)
Pages (from-to)89-97
Number of pages9
JournalGastroenterology
Volume138
Issue number1
DOIs
StatePublished - Jan 2010

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Constipation
Fasting
Phenotype
Compliance
Healthy Volunteers
Logistic Models
Principal Component Analysis
Colon
Motor Activity
Pressure

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Phenotypic Variation of Colonic Motor Functions in Chronic Constipation. / Ravi, Karthik; Bharucha, Adil Eddie; Camilleri, Michael; Rhoten, Deborah; Bakken, Timothy; Zinsmeister, Alan R.

In: Gastroenterology, Vol. 138, No. 1, 01.2010, p. 89-97.

Research output: Contribution to journalArticle

Ravi, Karthik ; Bharucha, Adil Eddie ; Camilleri, Michael ; Rhoten, Deborah ; Bakken, Timothy ; Zinsmeister, Alan R. / Phenotypic Variation of Colonic Motor Functions in Chronic Constipation. In: Gastroenterology. 2010 ; Vol. 138, No. 1. pp. 89-97.
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