Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus

Elena Sanchez, Ajay Nadig, Bruce C. Richardson, Barry I. Freedman, Kenneth M. Kaufman, Jennifer A. Kelly, Timothy B. Niewold, Diane L. Kamen, Gary S. Gilkeson, Julie T. Ziegler, Carl D. Langefeld, Graciela S. Alarcón, Jeffrey C. Edberg, Rosalind Ramsey-Goldman, Michelle Petri, Elizabeth E. Brown, Robert P. Kimberly, John D. Reveille, Luis M. Vilá, Joan T. MerrillJuan Manuel Anaya, Judith A. James, Bernardo A. Pons-Estel, Javier Martin, So Yeon Park, So Young Bang, Sang Cheol Bae, Kathy L. Moser, Timothy J. Vyse, Lindsey A. Criswell, Patrick M. Gaffney, Betty P. Tsao, Chaim O. Jacob, John B. Harley, Marta E. Alarcón-Riquelme, Amr H. Sawalha

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Objective: Systemic lupus erythematosus is a clinically heterogeneous autoimmune disease. A number of genetic loci that increase lupus susceptibility have been established. This study examines if these genetic loci also contribute to the clinical heterogeneity in lupus. Materials and methods: 4001 European-derived, 547 Hispanic, 1590 African-American and 1191 Asian lupus patients were genotyped for 16 confirmed lupus susceptibility loci. Ancestry informative markers were genotyped to calculate and adjust for admixture. The association between the risk allele in each locus was determined and compared in patients with and without the various clinical manifestations included in the ACR criteria. Results: Renal disorder was significantly correlated with the lupus risk allele in ITGAM (p=5.0 × 10-6, OR 1.25, 95% CI 1.12 to 1.35) and in TNFSF4 (p=0.0013, OR 1.14, 95% CI 1.07 to 1.25). Other significant findings include the association between risk alleles in FCGR2A and malar rash (p=0.0031, OR 1.11, 95% CI 1.17 to 1.33), ITGAM and discoid rash (p=0.0020, OR 1.20, 95% CI 1.06 to 1.33), STAT4 and protection from oral ulcers (p=0.0027, OR 0.89, 95% CI 0.83 to 0.96) and IL21 and haematological disorder (p=0.0027, OR 1.13, 95% CI 1.04 to 1.22). All these associations are significant with a false discovery rate of <0.05 and pass the significance threshold using Bonferroni correction for multiple testing. Conclusion: Significant associations were found between lupus clinical manifestations and the FCGR2A, ITGAM, STAT4, TNSF4 and IL21 genes. The findings suggest that genetic profiling might be a useful tool to predict disease manifestations in lupus patients in the future.

Original languageEnglish (US)
Pages (from-to)1752-1757
Number of pages6
JournalAnnals of the rheumatic diseases
Volume70
Issue number10
DOIs
StatePublished - Oct 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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    Sanchez, E., Nadig, A., Richardson, B. C., Freedman, B. I., Kaufman, K. M., Kelly, J. A., Niewold, T. B., Kamen, D. L., Gilkeson, G. S., Ziegler, J. T., Langefeld, C. D., Alarcón, G. S., Edberg, J. C., Ramsey-Goldman, R., Petri, M., Brown, E. E., Kimberly, R. P., Reveille, J. D., Vilá, L. M., ... Sawalha, A. H. (2011). Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Annals of the rheumatic diseases, 70(10), 1752-1757. https://doi.org/10.1136/ard.2011.154104